Author | Year | Model | Species | Effects of H2 | Proposed Mechanism |
---|---|---|---|---|---|
Ji et al. [14] | 2010 | TBI | Rat | Brain edema↓, neurological deficits↓ | H2 increased endogenous antioxidant enzymatic activities |
Eckermann et al. [18] | 2011 | SBI | Rat | Brain edema↓, neurological deficits↓ | None proposed |
Ohsawa et al [21] | 2007 | tMCAO | Rat | Brain infarction↓, neurological deficits↓ | H2 selectively inhibited OH- |
Matchett et al. [23] | 2009 | tMCAO | Rat | Tendentially reduced brain infarction | None proposed |
Chen et al. [24] | 2010 | tMCAO | Hyperglycemic rat | Hemorrhagic transformation↓ | H2 reduced hyperglycemia |
Liu et al. [22] | 2011 | tMCAO | Rat | Brain edema↓, infarction↓, neurological deficits↓ | ROS↓, inflammation↓, apoptosis↓ |
Manaenko et al. [27] | 2011 | ICH | Mouse | Acute brain edema↓, neurological deficits↓ | None proposed |
Zhan et al. [28] | 2012 | SAH | Rat | Acute brain edema↓, neurological deficits↓ | BBB permeability↓, ROS↓, apoptosis↓ |
Matchet et al. [23] | 2009 | HI | Mouse | No beneficial effects | None proposed |
Cai et al. [31] | 2008 | HI | Rat | Brain infarction↓, apoptosis↓ | H2 selectively inhibited caspase activity |