Figure 4

Seven-day treatment with naproxen, but not ATB-346, induces gastric mucosa damage and increased myeloperoxidase activity (MPO). MPO activity content (panel A) and tissue damage score (panel B), determined in rat stomach samples obtained from the different treatment group. Panel C: Representative pictures of stomachs obtained from each experimental group (pictures corresponding to the naproxen and ATB-346 groups are also shown at higher magnification); yellow arrows indicate the presence of erosions. ***P < 0.001 vs. all the remaining experimental groups (n = 5 for each group).