Table 1 Hypoxic-ischemic encephalopathy (HIE)
From: Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?
Animal model/Cell line | HBO therapy | Method/Duration | Neurogenesis | Infarct size | Neurobehavioral testing | Mechanism | Institute | Reference |
|---|---|---|---|---|---|---|---|---|
HIE rats | Within 3 h 100%, 2 ATA 1 h/d × 7 | BrdU 50 mg/Kg 2 days before sac Q8hX5T | SVZ ↑Brdu+/nestin+ D3, D7, D14 after ischemia | / | / | Wnt-3 | Central South University, China | Wang, et al [4] |
HIE rats | Within 3 h 100%, 2 ATA 1 h/d × 7 | brdU 50 mg/Kg 1 days after surgery Q12hX6D | SVZ ↑Brdu+/nestin+ D3, D7, D14 after ischemia | / | / | MBP | Central South University, China | Yang, et al [11] |
HIE rats | Within 3 h 2 ATA, 100% oxygen 1 h/d × 7 | brdU 50 mg/Kg 1 days before HBO Q12hX6D | ↑D7 SVZ brdu+/DCX+ ↑D14 cortex brdu+/DCX+ D28 cortex ↑BrdU/GFAP/tubulin | / | / | / | Central South University, China | Wang, et al [5] |
neural stem cell from HIE rats | Within 2 h 2 ATA, 100% oxygen × 1 h | / | differentiate into ↑neurons ↑oligodendrocytes ↓astrocytes | / | / | β-catenin, | Central South University, China | Zhang, et al [6] |