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Table 1 Hypoxic-ischemic encephalopathy (HIE)

From: Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Animal model/Cell line HBO therapy Method/Duration Neurogenesis Infarct size Neurobehavioral testing Mechanism Institute Reference
HIE rats Within 3 h 100%, 2 ATA 1 h/d × 7 BrdU 50 mg/Kg 2 days before sac Q8hX5T SVZ ↑Brdu+/nestin+ D3, D7, D14 after ischemia / / Wnt-3 Central South University, China Wang, et al [4]
HIE rats Within 3 h 100%, 2 ATA 1 h/d × 7 brdU 50 mg/Kg 1 days after surgery Q12hX6D SVZ ↑Brdu+/nestin+ D3, D7, D14 after ischemia / / MBP Central South University, China Yang, et al [11]
HIE rats Within 3 h 2 ATA, 100% oxygen 1 h/d × 7 brdU 50 mg/Kg 1 days before HBO Q12hX6D ↑D7 SVZ brdu+/DCX+ ↑D14 cortex brdu+/DCX+ D28 cortex ↑BrdU/GFAP/tubulin / / / Central South University, China Wang, et al [5]
neural stem cell from HIE rats Within 2 h 2 ATA, 100% oxygen × 1 h / differentiate into ↑neurons ↑oligodendrocytes ↓astrocytes / / β-catenin, Central South University, China Zhang, et al [6]