Table 1 Open-label trial of HEW in 14 myopathic patients

CK (U/L)

3067 ± 1492

3419 ± 1610

3107 ± 2382

124 ± 31

180 ± 97

140 ± 86

187 ± 75

124 ± 47

156 ± 40

HbA1c (%)

5.25 ± 0.44

5.14 ± 0.31

5.16 ± 0.42

6.68 ± 1.61

6.70 ± 1.53

6.90 ± 2.03

7.40 ± 1.70

7.32 ± 1.48

7.38 ± 1.74

Fasting glucose (mmol/L)

5.52 ± 0.16**

5.51 ± 0.08**

5.82 ± 0.11**

7.66 ± 0.11

7.29 ± 1.57

7.69 ± 1.85

8.94 ± 3.24

9.31 ± 4.18

8.96 ± 3.19

Lactate

(mmol/L)

0.95 ± 0.34

1.15 ± 0.40

1.35 ± 0.40

1.42 ± 0.18

1.66 ± 0.32

1.30 ± 0.27

1.84 ± 0.50

1.87 ± 0.78

1.73 ± 0.65

L/P

ratio

12.1 ± 0.7*

10.7 ± 1.3*

13.6 ± 2.2*

13.1 ± 0.9

15.0 ± 3.2

12.7 ± 1.0

20.7 ± 2.9*

14.9 ± 3.5*

20.3 ± 3.1*

Creatinine (μmol/L)

34.8 ± 3.1

34.5 ± 6.9

34.7 ± 8.8

58.6 ± 13.7

56.3 ± 10.7

56.6 ± 14.1

48.8 ± 9.0

47.7 ± 9.7

48.6 ± 8.8

BUN (mmol/L)

4.74 ± 1.16

4.20 ± 0.60

4.21 ± 1.05

4.33 ± 0.71

4.11 ± 0.48

4.68 ± 0.74

5.28 ± 1.69

5.89 ± 1.09

5.00 ± 1.58

Uric acid (μmol/dL)

295 ± 46

315 ± 61

300 ± 30

319 ± 44

331 ± 71

329 ± 40

208 ± 50

220 ± 60

217 ± 45

Urinary 8-isoprostane

(ng/mg Cr)

303 ± 155

392 ± 173

n.d.

222 ± 88

237 ± 86

n.d.

274 ± 117

261 ± 59

n.d.

T-chol (mmol/L)

5.42 ± 0.99

5.74 ± 1.02

5.70 ± 0.81

5.28 ± 0.31

5.55 ± 0.93

5.97 ± 1.35

4.52 ± 0.75

4.53 ± 0.34

4.42 ± 0.77

LDL-chol (mmol/L)

3.30 ± 1.05

2.86 ± 1.46

2.99 ± 1.15

2.66 ± 0.28

3.21 ± 0.99

3.13 ± 1.02

2.44 ± 0.43

2.27 ± 0.44

2.22 ± 0.45

HDL-chol (mmol/L)

1.62 ± 0.21

1.49 ± 0.19

1.62 ± 0.18

2.01 ± 0.73

1.99 ± 0.76

2.02 ± 0.67

1.14 ± 0.79

1.03 ± 0.72

1.04 ± 0.69

Triglycerides (mmol/L)

1.31 ± 0.46

3.62 ± 4.83

3.07 ± 3.67

2.17 ± 0.63*

2.01 ± 1.21^*

3.09 ± 1.22*

0.78 ± 0.34

0.89 ± 0.45

0.73 ± 0.37

WBC (10⁹/L)

5.30 ± 1.32

5.40 ± 1.12

4.80 ± 0.38

10.78 ± 2.08

8.35 ± 3.41

10.10 ± 0.17

5.12 ± 1.27

7.27 ± 2.29

5.93 ± 1.35

RBC (10¹²/L)

4.17 ± 0.64

3.79 ± 0.42

3.87 ± 0.80

4.01 ± 0.62

4.34 ± 0.36

4.49 ± 0.45

4.33 ± 0.43

4.31 ± 0.78

4.35 ± 0.59

Platelets (10⁹/L)

262 ± 42

260 ± 33

270 ± 20

337 ± 123

265 ± 82

270 ± 65

215 ± 25

207 ± 28

217 ± 25

Hematocrit

0.375 ± 0.040

0.374 ± 0.038

0.407 ± 0.055

0.337 ± 0.069

0.376 ± 0.041

0.395 ± 0.045

0.381 ± 0.036

0.370 ± 0.047

0.378 ± 0.038

MMP3 (ng/ml)

n.d.

n.d.

n.d.

307.8 ± 59.1*

224.3 ± 53.4*

283.3 ± 77.6*

n.d.

n.d.

n.d.

IgG (mg/dl)

n.d.

n.d.

n.d.

1343 ± 470

1396 ± 550

1429 ± 581

n.d.

n.d.

n.d.