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Table 1 Ozone therapy can induce the following biological responses

From: Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

a) Improves blood circulation and oxygen delivery in ischemic tissue owing to NO, CO, and increase levels of intra-erythrocytic 2, 3-DPG.
b) Enhances general metabolism by improving oxygen delivery.
c) Upregulates cellular antioxidant enzymes and induction of HO-1 and HSP70.
d) Induces a mild activation of the immune system and enhances the release of growth factors.
e) Does not procure acute or late side effects.
f) Procures a surprising wellness in most patients, probably via the stimulation of the neuroendocrine system.
g) Activates neuroprotective systems.
  1. References: [46, 58, 81, 84, 119]