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Table 1 Ozone therapy can induce the following biological responses

From: Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

a)

Improves blood circulation and oxygen delivery in ischemic tissue owing to NO, CO, and increase levels of intra-erythrocytic 2, 3-DPG.

b)

Enhances general metabolism by improving oxygen delivery.

c)

Upregulates cellular antioxidant enzymes and induction of HO-1 and HSP70.

d)

Induces a mild activation of the immune system and enhances the release of growth factors.

e)

Does not procure acute or late side effects.

f)

Procures a surprising wellness in most patients, probably via the stimulation of the neuroendocrine system.

g)

Activates neuroprotective systems.

  1. References: [46, 58, 81, 84, 119]