Figure 1From: Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in ratsEffects of CO insufflation into the colonic lumen on macroscopic findings, mucosal damage score, and wet colon weight after trinitrobenzene sulfonic acid (TNBS)-induced injury. (A) Severe colitis was induced, including hyperemia, edema, thickening, ulceration, and necrosis, in TNBS-treated rats (normal air group). These changes were reduced in rats treated by CO insufflation into the colonic lumen (CO group). (B) The ulcer index was evaluated. *P < 0.01 compared to sham-operated rats. #P < 0.05 compared to rats with TNBS-induced colitis receiving normal air insufflation. (C) The wet colon weight was measured. Data represent the mean ± SEM of 7 rats. *P < 0.05 relative to sham-operated rats. #P < 0.05 relative to rats with TNBS-induced colitis receiving normal air insufflation.Back to article page