Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

Table 1 Clinical effects of high H₂water and patient characteristics at baseline, and 4, 8, and 12 weeks

	Patients		Disease duration		Urinary 8-OHdG (ng/mg Cr)				DAS28				ACPA (U/ml)				Medications
					Baseline	4w	8w	12w	Baseline	4w	8w	12w	Baseline	4w	8w	12w	MTX (mg/w)	Duration		Abatacept (mg/4w)	Duration		Response
Patient number	Sex	Age	Y	M														Y	M		Y	M
1	F	67	3	2	10.1	10.0	7.7	6.0	3.28	2.45	2.40	1.94	300	204	254	226	6	2	0	500	1	2	good
2	F	69	5	0	18.0	16.2	12.0	11.5	2.90	2.95	2.53	2.62	<0.6	<0.6	<0.6	<0.6	4	2	1				non-response
3	F	76	11	0	11.0	8.1	7.8	7.8	4.61	3.71	3.28	3.01	52.4	47.2	58.0	56.6	6	3	0				good
4	F	51	2	1	11.4	11.3	9.1	9.4	3.00	2.79	2.86	2.30	<0.6	<0.6	<0.6	<0.6	6	1	6				moderate
5	F	41	2	0	10.9	9.9	11.3	10.0	4.55	3.43	3.06	3.13	6.9	6.2	9.2	14.5	none						good
6	F	42	2	2	15.3	12.6	11.6	10.8	4.63	4.03	2.44	2.57	<0.6	<0.6	<0.6	<0.6	6	1	4				good
7	F	86	5	0	10.0	6.5	7.1	7.1	4.67	3.79	3.78	3.00	0.8	<0.6	<0.6	<0.6	none						good
8	F	40	10	0	nd	nd	3.9	4.9	2.88	1.25	1.50	0.99	13.5	14.5	15.4	16.8	6	2	2				good
9	F	41	2	1	8.7	7.7	7.3	9.0	5.38	4.35	4.37	4.22	34.3	36.4	57.6	65.7	8	1	6				moderate
10	M	55	2	3	9.3	8.3	9.7	11.5	4.62	3.44	3.28	3.06	532	258	299	223	6	1	8				good
11	F	56	2	0	12.0	8.2	10.8	10.9	5.47	5.22	5.06	4.16	<0.6	<0.6	<0.6	<0.6				500	0	8	good
12	M	40	2	1	5.2	4.9	4.9	6.4	1.95	1.96	1.52	1.59	<0.6	<0.6	<0.6	<0.6	6	1	4				non-response
13	F	64	13	0	nd	8.1	11.2	9.0	2.72	2.14	2.32	2.21	490	299	266	256	4	7	0				non-response
14	F	58	2	0	10.7	8.4	8.5	10.5	3.21	3.03	2.93	3.04	<0.6	<0.6	<0.6	<0.6	6	1	2				non-response
15	F	74	3	0	6.5	6.8	5.7	5.3	2.91	2.52	2.30	1.30	<0.6	<0.6	<0.6	<0.6	none						good
16	F	69	0	8	7.6	6.5	8.6	5.4	4.07	2.78	2.54	0.99	2	3.7	<0.6	1.9	none						good
17	M	42	0	9	7.9	5.7	6.6	7.2	3.25	2.03	2.27	1.11	<0.6	<0.6	<0.6	<0.6	6		6				good
18	F	49	0	5	10.6	8.5	7.2	9.3	4.91	3.46	2.83	1.17	<0.6	<0.6	<0.6	<0.6	none						good
19	F	57	0	10	9.5	9.4	9.2	10.7	3.38	2.87	2.50	1.82	<0.6	<0.6	<0.6	<0.6	none						good
20	F	41	0	8	5.2	5.0	4.4	3.8	4.20	2.29	2.91	0.99	<0.6	<0.6	<0.6	<0.6	none						good

And, no urine sample; DAS28, disease activity score in 28 joints; ACPA, antibodies against cyclic citrullinated peptides.

ISSN: 2045-9912