Figure 1
From: Exploring the potential of low doses carbon monoxide as therapy in pregnancy complications
Effect of moderate (125 ppm ) and low (50 ppm ) CO concentration during implantation window on murine pregnancy outcome. (a) Pregnant mice treated with 125 ppm of CO during implantation window (days 3-5 of pregnancy) show sligthly diminished fetal loss rate compared to air-treated controls as analyzed on day 14 of pregnancy (b) Maternal COHb and (c) tHb levels were comparable among the groups. (d, e) Treatment with 125 ppmof CO provoked the pregnant mice to carry abnormal fetuses (d, e). Exposure of pregnant females to 50 ppmof CO during days 3-5 of pregnancy did not modify pregnancy outcome when compared to air-treated controls (g). Neither COHb (h) nor tHb levels (i) in maternal blood were modified by this treatment. The data are shown as medians. *p < 0.05, as analyzed by the non-parametric Mann-Whitney U-test between two groups.