Figure 2

CO treatment applied during embryo implantation and early placentation positively influence pregnancy outcome. (a) Inhalation of low amounts of CO (50 ppm) during implantation and early placentation (days 3-8) completely prevented fetal loss as analyzed on day 14 of pregnancy. COHb (b) and tHb (c) levels in maternal blood were not modified by the treatment. 50 ppmCO applied during days 3-8 of pregnancy augmented the weight of fetuses (d) and placentas (e). Sacrificing the animals immediately after CO treatment (day 8 of pregnancy) revealed no differences in the levels of COHb and tHb among the groups (f and g). Data are shown as median. **p < 0.01, as analyzed by the non-parametric Mann-Whitney U-test between two groups. e-f data are shown as mean. ** < 0,01 as analyzed by unpaired t-test.