Example 1 of Predicted Lesion Volume Development. (A)Admission MRI dataset for a 79 year-old woman with stroke who was imaged 13 hours after she was last seen well and treated with NBO. (B)Corresponding GLM-predicted lesion risk maps (left panel) for Control and NBO-models at each subsequent time point of imaging, and overlay map (right panel) of differences between the two models showing ischemic tissue that is 'potentially salvageable' with NBO therapy. The GLM-predicted lesion volumes are asynthesis of data from the admission MRI only. In this patient, the risk of tissue infarction in DWI/PWI mismatch regions was predicted to increase over time. For clarity, only GLM-predicted lesion risk > 50% are shown overlaid on acute DWI. Note that the amounts of tissue predicted to infarct at all time-points with the Control-models were greater than their NBO-model counterparts, with difference principally in the DWI/PWI mismatch region (arrowheads). In the difference maps (B, right panel), the color scale represents infarction risk reduction as a result of NBO-therapy (conversely, larger values represent greater likelihood of infarction if the patient was given Control-treatment).