Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models

Medical Gas Research

Table 2 GLM Coefficients for the different models (Mean ± SD) for predicting lesion development

Models	Bias	T₂WI	ADC	iDWI	CBF	CBV	MTT	Tmax
Models Predicting 4 h Lesion Development (during treatment)
Control	-11 ± 1.4§	4.0 ± 1.0§	-4.3 ± 1.3§	9.3 ± 1.2§	-0.9 ± 0.2	0.7 ± 0.1	0.5 ± 0.2	0.07 ± 0.008§
NBO	-17 ± 0.8§	2.0 ± 0.3§	0.10 ± 0.3*§	11 ± 0.5§	-0.4 ± 0.2*§	-0.02 ± 0.2*	0.9 ± 0.2	0.05 ± 0.008§
Models Predicting 24 h Lesion Development (post-treatment)
Control	-3.1 ± 1.0†	8.1 ± 0.8†	-9.1 ± 1.0†	2.3 ± 0.8†	-0.7 ± 0.1	0.5 ± 0.1	0.5 ± 0.1	0.05 ± 0.007†
NBO	-13 ± 0.5†	0.6 ± 0.2†	1.0 ± 0.2†	8.9 ± 0.3†	0.2 ± 0.09†	-0.2 ± 0.08	1.3 ± 0.1	0.1 ± 0.006†
*Models Predicting Discharge Lesion Development*
Control	-3.4 ± 0.6†	4.2 ± 0.4§	-5.1 ± 0.5§	2.7 ± 0.5†	-0.7 ± 0.1	0.5 ± 0.08	0.9 ± 0.1§†	0.06 ± 0.006
NBO	-8.8 ± 0.3†§	0.3 ± 0.1†	0.7 ± 0.2	6.1 ± 0.2†§	-0.2 ± 0.09*§	-0.06 ± 0.07*	0.9 ± 0.09§	0.1 ± 0.006†

*P > 0.05 Non-significant coefficients
†P < 0.05 vs coefficients of 4 h models, §P < 0.05 vs coefficients of 24 h models
Coefficients for Control- and NBO-models were significantly different (P < 0.05) with the exception of T₂WI, iDWI, CBF and Tmax for 4 h and MTT for 1-week time points (displayed in light-gray).

ISSN: 2045-9912