From: Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis
Author, year, country | Type of study | Number of patients improved/number treated | HBOT parameters | Side effects | Comments/outcomes |
---|---|---|---|---|---|
Buchman et al. 2001 [12], USA | Case report | 1/1 | 2.0 ATA 100% oxygen; 2 h duration; 5 days per week; 30 total treatments | NR | Pancolonic ulcerative colitis refractory to conventional medical treatments (corticosteroids for 22 months, 6-mercaptopurine, mesalamine and tetracycline); significant improvements and clinical remission with HBOT (effect lasted 2 months) |
Demirturk et al. 2002 [50], Turkey | Case series†| 2/2; one from (Hulagu et al. 1997) [52] | 2.0 ATA 100% oxygen; 2 h duration; 30 days of treatment | none | Pancolitis in 2 patients with ulcerative colitis was refractory to standard medical treatments (mesalamine and prednisolone); in the first patient during the third week of HBOT, significant improvements were observed; in second patient, improvements observed within 2 weeks; resolution of bloody diarrhea noted in both cases |
Gurbuz et al. 2003 [51], Turkey | Case report; letter to editor | 1/1 | 2.0 ATA 100% oxygen; 2 h duration; 35 days of treatment | NR | Left-sided ulcerative colitis was refractory to standard medical treatments (5-amino salicylic acid, methylprednisolone and azathioprine); improvements and clinical remission observed with HBOT after 2 weeks of treatment; remission lasted for at least 6 months |
Hulagu et al. 1997 [52], Turkey | Case report | 1/1 | 2.0 ATA 100% oxygen; 2 h duration; 1 treatment per day for 30 days | none | Patient had ulcerative pancolitis; exacerbation was refractory to standard medical treatments (mesalazine and total parenteral nutrition); by third week of HBOT, "definite improvement" observed |
Karkumov et al. 1991 [53], Bulgaria | Case series††| 34/34 | 10-12 treatments at 60-75 min; other parameters not reported | NR | All patients had chronic ulcerohemorrhagic colitis; all patients improved after first 5-6 treatments |
Kuroki et al. 1998 [54], Japan | Case report | 1/1 | 2 ATA; 60 min duration; 1 treatment per day; 27 days | none | Patient had refractory ulcerative colitis and toxic megacolon (failed antibiotics and intravenous prednisolone); IL-6 dropped from 13.2 to 7.2 pg/ml after 1 HBOT session; significant clinical improvements after third day of HBOT |