From: Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis
Author, year, country | Animal used | Number of animals | HBOT parameters | Comments/outcomes |
---|---|---|---|---|
Akin et al. 2002 [55], Turkey | Rat | 42 | 2.0 ATA 100% oxygen; 2 h treatments for 2 (acute) or 14 (chronic) days | HBOT studied in acute (2 days) and chronic (14 days) colitis; compared to sham treatment, HBOT significantly ameliorated macroscopic, but not microscopic, damage in chronic colitis but not acute colitis; HBOT also significantly reduced myeloperoxidase activity (an index of the accumulation of neutrophils) in acute colitis and decreased plasma carbonyl content (a marker of oxidative damage) in chronic colitis |
Altinel et al. 2011 [56], Turkey | Rat | 40 | 2.8 ATA 100% oxygen; 90 min treatments; 2 treatments per day for 5 days | Compared to sham treatment, HBOT significantly reduced the severity of colitis as measured by a histopathological score; HBOT also significantly reduced malondialdehyde (a marker of oxidative stress) and neopterin (a marker of cell-mediated immune activation). |
Atug et al. 2008 [57], Turkey | Rat | 48 | 2.0 ATA 100% oxygen; 75 min in duration; 2 treatments per day for up to 3 days | Compared to sham treatment, HBOT significantly decreased colitis on microscopic, macroscopic and tissue weight testing; HBOT also significantly decreased myeloperoxidase activity; HBOT was equivalent to dexamethasone in anti-inflammatory effect |
Ercin et al. 2009 [58], Turkey | Rat | 36 | 2.4 ATA 100% oxygen; 1 h duration; 2 treatments per day for 7 days | Compared to sham treatment, HBOT significantly decreased colitis on both microscopic and macroscopic testing compared to control group and prevented weight loss; HBOT also significantly reduced nitric oxide levels |
Gorgulu et al. 2006 [59], Turkey | Rat | 50 | 2.8 ATA 100% oxygen; 90 min duration; 2 treatments per day for 3 days | Compared to sham treatment, HBOT significantly reduced histopathologic score of inflammation; HBOT slightly reduced myeloperoxidase activity but not significantly |
Gulec et al. 2004 [60], Turkey | Rat | 36 | 2.5 ATA; 90 min duration; 2 treatments per day for 5 days | HBOT significantly reduced malondialdehyde levels in erythrocytes, plasma and intestinal tissue; HBOT significantly increased glutathione peroxidase and superoxide dismutase levels; HBOT significantly improved histopathological scores |
Guven et al. 2009 [61], Turkey | Rat | 30 | 2.8 ATA 100% oxygen; 90 min duration for 3 days | HBOT significantly reduced malondialdehyde levels, nitric oxide levels, TNF-alpha levels, and protein carbonyl content; HBOT significantly increased glutathione peroxidase and superoxide dismutase levels; HBOT significantly reduced histological evidence of intestinal injury |
Guven et al. 2010 [62], Turkey†| Rat | 40 | 2.8 ATA 100% oxygen; 90 min duration; 2 treatments per day for 4 days | HBOT reduced malondialdehyde levels (non-significantly); HBOT decreased inflammation and edema compared to controls |
Nandi et al. 2010 [63], USA | Rat | NR | 2.3 ATA 100% oxygen; 1 h duration for 2-5 days | HBOT significantly decreased indomethacin-induced ulceration and reduced TNF-α, IL-1β, nitric oxide, nitric oxide synthase levels as well as myeloperoxidase activity |
Rachmilewitz et al. 1998 [64], Israel | Rat | 56 | 2.4 ATA 100% oxygen; 1 or 7 days in duration | HBOT significantly decreased colonic tissue weight, myeloperoxidase levels, Prostaglandin E2 generation and nitric oxide synthase activity; HBOT significantly decreased colitis on histological examination |
Simsek et al. 2011 [65], Turkey††| Rat | 20 | 2.5 ATA 100% oxygen; 60 min duration | HBOT significantly decreased intestinal injury as measured by an apoptosis score and significantly increased protein carbonyl content |
Yang et al. 2006 [66], USA | Rat | 48 | 2.3 ATA 100% oxygen; 60 min duration; 1-2 treatments per day for 2 or 5 days | HBOT significantly decreased TNF-α and IL-1β; HBOT significantly reduced intestinal ulceration; HBOT significantly reduced myeloperoxidase and nitric oxide synthase activities |