Figure 4

HBO preconditioning significantly reduced Evans blue extravasation. Animals were injected with Evans blue 23 h after MCAO. At 1 h after injection, animals were sacrificed after cardiac perfusion and quantitative evaluation analysis was evaluated. Extravasated Evans blue dye was significantly reduced by HBO-PC. *P > 0.05 vs. htMCAO, ^#P > 0.05 vs. sham.