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Figure 2 | Medical Gas Research

Figure 2

From: Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water

Figure 2

Characterization of functional and histological changes in pictures. A Representative histological findings in the kidneys of rats fed FW or EW for 43 weeks. Enhanced interstitial fibrosis in the outer renal medulla is observed in the FW (a) group compared to the EW (b) group. Exaggerated tubular dilatations are present in the FW (c) group as compared to the EW (d) group. Nitrotyrosine (e), number of ED-1 positive cells (→) (g), and malondialdehyde (i) were increased in the FW (g, j, m) group as compared to the EW (f, h, i) group in the renal cortex of rats. B. Representative histological findings in the hearts of rats fed FW or EW for 48 weeks. Enhanced cardiac fibrosis is found in the FW (a), compared to the EW (b) group. Staining of nitrotyrosine positive cells (→) (c), number of ED-1 positive cells (→) (e), and malondialdehyde (g) were observed in the FW group, while faint staining was observed in the EW (d, f, h) group in the renal cortex of rats. Increased Nrf2 staining was observed in the EW (j) group as compared to the FW (i) group.

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