Figure 3
Potential sites of vasculoprotective effects of H 2 S. Cartoon depicting a cross section of the vascular wall showing the endothelium, intima containing smooth muscle cells overlaying the vascular media. A. H2S has been shown to decrease leukocyte adhesion and migration [60] and differentiation to foam cells [64]. B. H2S can inhibit the production of ROS [39, 40] as well as scavenge ROS [35–38], protecting endothelial function. C H2S prevents proliferation [66] and promotes apoptosis of vascular smooth muscle cells [67]D. H2S prevents collagen deposition [51] and neo-intima formation [65]. E H2S can inhibit platelet adhesion [26] and aggregation [25].