Figure 3
Multiple HBO treatment mildly improved the neurological deficits in hydrocephalic animals. (A) 14 days after SAH, the foot fault times in left forelimb were significantly higher than that in Sham group. Hydrocephalus deteriorated the performance, and HBO treatment showed tendency to improve the performance and removed the significance between SAH w/t HyC. (B) After SAH, there is no significant reduce of muscle strength between hydrocephalic and non-hydrocephalic animals. HBO treatment did not increase the time of wire hanging. (C) In accelerating rotarod, hydrocephalic animals more easily fell off from the rotarod than non-hydrocephalic rats, and HBO treatment showed minor improvement by eliminating the significance between SAH w/t HyC. (D) At 21 days after surgery, there is significant difference in body weight between Sham-operated animals and the SAH-operated animals, but no difference between the SAH-operated with HBO or NBO treatment groups. Sham, n = 8; SAH w/t HyC, n = 6; SAH/HyC, n = 4; SAH/HyC + HBO, n = 4; SAH/HyC + NBO, n = 4. *p < 0.05 compared with Sham, #p < 0.05 compared with SAH w/t HyC.