Figure 4

Multiple HBO treatment improved spatial learning and memory abilities in hydrocephalic animals. When compared with Sham group, the animals in SAH w/t HyC group had a significantly greater distance moved from the target (A), need more time to reach the platform (B), showed less frequency in target quadrants (C), spent less time in the probe quadrants (D). Hydrocephalus exacerbated the performance. Multiple HBO treatment did not showed significant improvement of memory and learning abilities when compared with SAH/HyC group, but removed the difference between SAH w/t HyC group. Sham, n = 8; SAH w/t HyC, n = 6; SAH/HyC, n = 4; SAH/HyC + HBO, n = 4; SAH/HyC + NBO, n = 4. *p < 0.05 compared with Sham, #p < 0.05 compared with SAH w/t HyC.