Figure 1
From: In vitroActivation of heme oxygenase-2 by menadione and its analogs
Lack of effect of vitamins K 1 and K 2 on HO-1 and HO-2 activity in vitro. HO-1 and HO-2 activity were measured as described in Methods using spleen (solid triangles) and brain (open circles) microsomes, respectively. The abscissa shows drug concentration and ordinate shows HO-2 activity as a percent of control in the absence of added drug. Panel a, Vitamin K1 and panel b, Vitamin K2. The structures of vitamins K1 and K2 in the panels to illustrate their differences from menadione.