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Table 1 HO-2 activation by naphthoquinones containing furan-carboxylic acid substituents

From: In vitroActivation of heme oxygenase-2 by menadione and its analogs

Structure

HO-2

HO-1

Structure

HO-2

HO-1

 

% Act.

% Act.

 

% Act.

% Act.

7110952633

276

96

7118340386

153

93

7118340392

288

85

7118340387

320

91

7118340396

326

78

7118340385

578

72

7118340391

368

80

7118340381

508

89

7118340395

457

66

7118340384

540

100

7118340416

548

79

7118340380

533

86

7118340415

566

79

7118340379

560

85

7116980337

586

84

718340374

602

91

7118340417

693

71

   
  1. Rat HO-1 and HO-2 activities were determined as described in Methods. Test compounds were used at a concentration of 100 μM. Activity is reported as a percentage of activity in the absence of test compound; control = 100%. The 10-digit numbers are Otava catalog numbers.
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Medical Gas Research

ISSN: 2045-9912

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