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Table 5 Lesser HO-2 activation by naphthoquinones containing various additional moieties

From: In vitroActivation of heme oxygenase-2 by menadione and its analogs

Structure

HO-2

HO-1

Structure

HO-2

HO-1

 

% Act.

% Act.

 

% Act.

% Act.

7116411293

107

99

7010100229

110

90

7116411335

108

100

70101100227

95

76

7116411344

105

97

7010100231

127

73

7010100236

113

93

7010100235

120

90

7010100240

102

95

7210710091

92

17

7010100225

119

74

   
  1. HO-1 and HO-2 activities were determined as described in Methods. Test compounds were used at a concentration of 100 μM. Activity is reported as a percentage of activity in the absence of test compound; control = 100%. The 10-digit numbers are Otava catalog numbers.