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Table 7 HO activity in the presence of benzoquinone-like and naphthoquinone-like compounds

From: In vitroActivation of heme oxygenase-2 by menadione and its analogs

Structure

% Act. HO-2 @ 100 μm

% Act. HO-1 @ 100 μm

Structure

% Act. HO-2 @ 100 μm

% Act. HO-1 @ 100 μm

1,4-cyclohexandione

105

103

α-tetralone

96

98

1,4-benzoquinone

2

-5

1,4-naphthoquinone

503

71

hydroquinone

108

102

   
  1. HO-1 and HO-2 activities were determined as described in Methods. Test compounds were used at a concentration of 100 μM. Activity is reported as a percentage of activity in the absence of test compound; control = 100%.
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Medical Gas Research

ISSN: 2045-9912

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