Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: a randomized controlled trial

Table 2 Comparison of mental status examination scores

	Desflurane n = 37	Sevoflurane n = 47	p-value
MMSE baseline (n = 84)	29.1	29.0	0.63
MMSE baseline (n = 84)	28.6 to 29.5	28.3 to 29.5	0.63
MMSE 1 hour after anesthesia (n = 84)	27.5	26.7	0.07
MMSE 1 hour after anesthesia (n = 84)	26.5 to 28.3	25.6 to 27.4	0.07
Change in MMSE at 1 hour (n = 84)	−1.3	−2.5	0.03
Change in MMSE at 1 hour (n = 84)	−2.2 to −0.5	−3.3 to −1.8	0.03
MMSE decreased at 1 hour # (%) yes	23 (62.2%)	40 (85.1%)	0.02
MMSE decrease at least 2 points 1 hour after anesthesia end # (%) yes	17 (46.0%)	32 (68.1%)	0.04
MMSE 6 hours after anesthesia (n = 81)	28.9	29.2	0.70
MMSE 6 hours after anesthesia (n = 81)	28.5 to 29.4	28.5 to 29.7	0.70
MMSE 24 hours after anesthesia (n = 78)	28.9	29.2	0.39
MMSE 24 hours after anesthesia (n = 78)	28.3 to 29.3	28.3 to 29.7	0.39

Table 2: Mini Mental Status Exam (MMSE) scores in patients anesthetized with sevoflurane or desflurane. Continuous data are presented as median, 95% confidence interval and were analyzed by Wilcoxon; categorical data were analyzed by Chi square. Three patients were discharged prior to obtaining the MMSE 6 hours after anesthesia and an additional 3 were discharged prior to obtaining the MMSE 24 hours after anesthesia. The MMSE was not significantly different between groups at any measurement time. While the MMSE obtained one hour after anesthesia end was more likely to decrease from baseline in sevoflurane than desflurane, this difference was less than considered clinically significant (not at least 2 points) and was not present at 6 or 24 hours after anesthesia.

ISSN: 2045-9912