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Figure 1 | Medical Gas Research

Figure 1

From: Hydrogen sulfide provides cardioprotection against myocardial/ischemia reperfusion injury in the diabetic state through the activation of the RISK pathway

Figure 1

Na 2 S therapy reduces the extent of myocardial injury in db/db diabetic mice following MI/R. (A) Representative midventricular photomicrographs of hearts from a non-diabetic mouse and from db/db diabetic mice treated with vehicle or Na2S (0.1 mg/kg) at the time of reperfusion. (B) Myocardial infarct size relative to the area-at-risk (INF/AAR) in non-diabetic and diabetic mice subjected to 30 minutes of ischemia followed by 4 hours of reperfusion. (C) Myocardial INF/AAR and (D) circulating troponin-I levels in db/db diabetic mice subjected to 30 minutes of ischemia followed by 4 hours of reperfusion. For these experiments, mice were treated with vehicle (Veh) or Na2S (0.05 to 1 mg/kg) at the time of reperfusion. (E) Myocardial INF/AAR in db/db mice subjected to 30 minutes of LCA ischemia and 24 hours of reperfusion. Vehicle or Na2S (0.1 mg/kg) was administered at the time of reperfusion. Values are mean ± SEM. Numbers inside of the bars indicate the number of animals that were investigated in each group. *p < 0.05 and **p < 0.01 vs. Vehicle; ***p < 0.001 vs. Vehicle or Non-Diabetic.

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