Figure 2
Na 2 S therapy reduces apoptosis and oxidative stress following MI/R. For these experiments, the extent of apoptosis and oxidative stress was evaluated in the hearts of db/db diabetic mice subjected to 30 minutes of ischemia and 4 hours of reperfusion. Mice were treated with Na2S (0.1 mg/kg) at the time of reperfusion. (A-B) Representative immunoblots and densitometric analysis of cleaved caspase-3. (C) Cleaved Caspase-3 Activity. (D) Heart MDA levels. Values are mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. Sham.