Figure 1
Ligature-induced alveolar bone loss and the inflammatory parameters is reduced in rats treated with naproxen or its H 2 S-releasing derivative ATB-346. Panel A: Distance from the cemento-enamel junction (CEJ) to the alveolar bone crest analyzed by digital X-ray images (n = 8). **P < 0.01 and ***P < 0.001 vs. Sham; #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. Vehicle. Histological aspect of gingival tissues. Panel B (4 × magnification): 1. Control, 2. Vehicle, 3. Na2S; panel C (20 × magnification): 4. Control, 6. Vehicle, 8. Naproxen, 10. ATB-346 (the respective inserts 5, 7, 9 and 11 are at a 10 × magnification). Δ: Giant cells; →: markedly reduced cellular infiltrate, preserved collagen fibers and gingival epithelium in comparison with the other groups.