Table 1 Physiological data and partition coefficients used for the model
Parameter | Mouse | Rat | Pig | Human (Adult Male) |
|---|---|---|---|---|
Body Weight (kg) | 0.025 | 0.25 | 25 | 70 |
Minute Ventilation (l.min-1) | 0.385 | 0.18 | 3.6 | 7.5 |
Alveolar Ventilation (l.min-1) | 0.025 | 0.117 | 2.34 | 4.875 |
Cardiac Output (l.min-1) | 0.017 | 0.083 | 2.060 | 6.0 |
Perfusion per compartment (as a fraction of Cardiac Output) | ||||
Fat (Richly perfused) | 0.09 | 0.09 | 0.1747 | 0.04 |
Fat (Poorly perfused) | NA | NA | NA | 0.01 |
Liver | 0.25 | 0.25 | 0.3052 | 0.26 |
Richly perfused tissue | 0.415 | 0.484 | 0.1829 | 0.3303 |
Poorly perfused tissue | NA | NA | 0.0553 | 0.01 |
Muscle | 0.15 | 0.15 | 0.2523 | 0.24 |
Brain | 0.095 | 0.026 | 0.0296 | 0.093 |
Volumes (fraction of Body Weight) | ||||
Arterial blood | 0.0110 | 0.0167 | 0.018 | 0.0209 |
Venous blood | 0.0331 | 0.050 | 0.042 | 0.0545 |
Lung blood | 0.0049 | 0.0074 | NA | 0.00245 |
Fat (Richly perfused) | 0.10 | 0.07 | 0.3 | 0.09 |
Fat (Poorly perfused) | NA | NA | NA | 0.09 |
Liver | 0.055 | 0.04 | 0.0294 | 0.06 |
Richly perfused tissue | 0.0454 | 0.0497 | 0.0697 | 0.0624 |
Poorly perfused tissue | NA | NA | 0.1269 | 0.24 |
Muscle | 0.66 | 0.676 | 0.4 | 0.44 |
Brain | 0.0046 | 0.0003 | 0.004 | 0.0176 |
Partition coefficients for Xenon | ||||
Blood:gas | 0.207 | 0.207 | 0.11 | 0.14 |
Fat:blood | 6.2802 | 6.2802 | 11.8182 | 9.287 |
Liver:blood | 0.7246 | 0.7246 | 1.3636 | 1.071 |
Richly perfused tissue:blood | 0.6951 | 0.7229 | 1.3774 | 1.071 |
Poorly perfused tissue:blood | 0.7246 | 0.7246 | 1.3636 | 1.071 |
Muscle:blood | 0.7246 | 0.7246 | 1.3636 | 1.071 |
Brain:blood | 1.1233 | 1.015 | 1.1233 | 1.123 |
Partition coefficients for Argon | ||||
Blood:gas | 0.037 | 0.037 | 0.037 | 0.037 |
Fat:blood | 4.1622 | 4.1622 | 4.1622 | 4.162 |
Liver:blood | 0.7539 | 0.7539 | 0.7539 | 0.754 |
Richly perfused tissue:blood | 1.0663 | 1.0323 | 1.0506 | 1.028 |
Poorly perfused tissue:blood | 0.9987 | 0.9987 | 0.9987 | 0.999 |
Muscle:blood | 0.7205 | 0.7205 | 0.7205 | 0.720 |
Brain:blood | 0.6747 | 0.6747 | 0.6747 | 0.675 |