Table 2 Pharmacokinetic results for a 60 min exposure to 50 % xenon or argon mixture with oxygen

Xenon Human

Blood (venous)

1.31E-01

2.54E-03

3.64

42.0

Blood (arterial)

1.61E-01

2.78E-03

0.21

2.4

Liver

1.64E-01

2.98E-03

2.87

33.1

Muscle

1.10E-01

2.73E-03

15.83

182.7

Fat (Richly perfused)

1.66E-01

5.46E-03

29.12

336.1

Fat (Poorly perfused)

4.41E-02

1.49E-03

30.42

351.1

Richly perfused tissue

1.64E-01

2.94E-03

2.40

27.6

Poorly perfused tissue

1.58E-03

5.23E-04

29.44

339.8

Brain

1.73E-01

3.12E-03

2.52

29.1

Xenon Pig

Blood (venous)

8.63E-02

1.77E-03

4.62

53.3

Blood (arterial)

1.26E-01

2.16E-03

0.19

2.2

Liver

1.67E-01

2.95E-03

1.59

18.4

Muscle

1.03E-01

2.61E-03

16.91

195.2

Fat

1.64E-01

5.37E-03

28.98

334.5

Richly perfused tissue

1.54E-01

2.97E-03

5.31

61.3

Poorly perfused tissue

8.42E-02

2.30E-03

20.40

235.4

Brain

1.37E-01

2.43E-03

1.79

20.7

Xenon Rat

Blood (venous)

9.84E-01

3.41E-03

0.31

3.6

Blood (arterial)

1.20E + 00

4.05E-03

0.05

0.6

Liver

8.66E-01

2.93E-03

0.35

4.1

Muscle

2.46E-01

1.14E-03

2.29

26.4

Fat

1.52E + 00

7.15E-03

2.39

27.6

Richly perfused tissue

8.74E-01

2.94E-03

0.26

3.0

Brain

1.22E + 00

4.11E-03

0.09

1.0

Argon Human

Blood (venous)

3.74E-02

7.02E-04

2.71

31.3

Blood (arterial)

4.41E-02

7.49E-04

0.18

2.1

Liver

3.21E-02

5.64E-04

1.89

21.8

Muscle

2.37E-02

5.26E-04

11.25

129.9

Fat (Richly perfused)

4.18E-02

1.30E-03

26.55

306.4

Fat (Poorly perfused)

1.19E-02

3.93E-04

29.48

340.3

Richly perfused tissue

4.36E-02

7.70E-04

2.07

23.9

Poorly perfused tissue

4.35E-03

1.42E-04

28.93

333.8

Brain

2.90E-02

5.05E-04

1.46

16.8