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Table 2 Disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants (321 original articles published in English) for which the effects of hydrogen have been reported from 2007 to June 2015

From: Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

Diseases and conditions References
Brain  
Cerebrovascular diseases (CVD)  
 Cerebral I/R injury [1, 10, 56, 83, 94, 99109]
 Hypertensive stroke [110]
 Brain injury secondary to intracerebral hemorrhage [28]
 Subarachnoid hemorrhage [48, 61, 66, 73, 111113]
Brain injury other than CVD  
 Traumatic brain injury [114118]
 Deep hypothermic circulatory arrest-induced brain damage [57]
Neurodegenerative diseases  
 Parkinson’s disease [11, 9597, 119]
 Alzheimer’s disease [43, 120]
Others  
 Restraint-induced dementia [121]
 Senile dementia in senescence-accelerated mice [122]
 LPS-induced neuroinflammation [81, 123]
 Oxidative stress-induced neuronal cell damage [124, 125]
Spinal Cord and peripheral nerve  
 Spinal cord I/R injury [126, 127]
 Spinal cord injury [77, 128]
 Neuropathic pain [39, 92, 129, 130]
 Hyperalgesia [79, 131, 132]
Eye  
 Retinal I/R injury [133, 134]
 Diabetic retinopathy [135, 136]
 Hyperoxia-induced retinopathy [137]
 Light-induced retinopathy [138, 139]
 Glutamine-induced retinopathy [50]
 S-nitroso-N-acetylpenicillamine-induced retinopathy [140]
 Optic nerve crush [141]
 Selenite-induced cataract [142]
 Corneal alkali-burn [55]
 Anti-inflammatory effects on LPS-activated retinal microglia cells [64]
Ear  
 Hearing loss [143148]
 Cisplatin-induced ototoxicity [149, 150]
 Ouabain-induced ototoxicity [151]
Oral Cavity  
 Periodontitis [32]
 Periodontal oxidative damage [152]
Lung  
 Lung I/R injury [153, 154]
 Oxygen-induced lung injury [82, 155, 156]
 Ventilation-induced lung injury [53, 157]
 LPS-induced acute lung injury [13, 14, 16, 158]
 Intestinal I/R-induced lung injury [159]
 Burn-induced lung injury [160]
 Paraquat-induced lung injury [161, 162]
 igarette smoking lung injury [163]
 Smoke inhalation lung injury [74]
 Pulmonary hypertension [78, 164]
Heart  
 Myocardial infarction and I/R injury [1724, 84]
 Diabetic cardiomyopathy [40]
 Sleep apnea-induced left ventricular remodeling [165, 166]
 Ventricular hypertrophy [167]
Stomach  
 Stress-induced gastric ulceration [38]
 Aspirin-induced gastric ulceration [168, 169]
Intestine  
 Intestinal I/R injury [170, 171]
 Ulcerative colitis [172, 173]
 Colon inflammation [174]
 Sepsis-induced intestinal injury [87]
 Necrotizing enterocolitis [175]
Liver  
 Liver I/R injury [71, 98, 176178]
 Chronic hepatitis B [179]
 Nonalcoholic steatohepatitis [180]
 Liver injury induced by massive hepatectomy [67, 93, 181]
 Liver injury induced by obstructive jaundice [31]
 Liver injury induced by endotoxin [35]
 Liver injury induced by acetaminophen [47]
 Liver injury induced by carbon tetrachloride [42]
 Liver injury induced by concanavalin A [182]
 Liver cirrhosis [183]
 Liver fibrosis [184]
Pancreas  
 Acute pancreatitis [76, 185187]
Peritoneum  
 Acute peritonitis [68]
Kidney  
 Renal I/R injury [188190]
 Acute renal injury [37, 72, 191194]
 Hypertensive renal injury [69]
 Cisplatin-induced nephropathy [195197]
 Gentamicin-induced nephrotoxicity [198]
 Inhibition of AGEs production [199]
 Renal calcium deposition [200]
Bladder  
 Interstitial cystitis [201]
Reproductive organ  
 Testicular I/R injury [202, 203]
 Erectile dysfunction [204]
 Nicotine-induced testicular oxidative stress [205]
 Cigarette smoke-induced testicular damage [206]
Skin  
 I/R injury [46, 207]
 UV-induced skin injury [45, 208211]
 Acute erythematous skin disease [212]
 Atopic dermatitis [213, 214]
 Psoriasis [215]
 Pressure ulcer [216]
 Burn [49, 70]
 Arsenic toxicity [217]
Bone and Joint  
 Rheumatoid arthritis [218, 219]
 Osteoporosis [36, 62]
 Bone loss induced by microgravity [34]
 TNFα-induced osteoblast injury [220]
 NO-induced cartilage toxicity [221]
Skeletal Muscle and soft tissue  
 I/R injury in skeletal muscle [222]
 Inflammatory and mitochondrial myopathies [223]
 Muscle fatigue [224]
 Sports-related soft tissue injury [225]
Blood vessel  
 Atherosclerosis [58, 59, 85, 226, 227]
 AGEs-induced blood vessel damage [228]
 Neointimal hyperplasia [29]
 Hyperplasia in arterialized vein graft [229]
 Vascular dysfunction [60]
 Vascular endothelial function [230]
Blood and Bone Marrow  
 Aplastic anemia [231]
 Maintenance of multipotential stroma/mesenchymal stem cells [232]
 Neutrophil function [233]
 Inhibition of collagen-induced platelet aggregation [234]
 Improvement of blood fluidity [235]
Metabolism  
 Diabetes mellitus [236241]
 Hyperlipidemia [44, 242244]
 Metabolic syndrome [245247]
 Metabolic process-related gene expression [248]
 Oxidized low density lipoprotein-induced cell toxicity [54]
 Serum alkalinization [249]
 Exercise-induced metabolic acidosis [250]
Inflammation/Allergy  
 Sepsis [41, 86, 251255]
 LPS/IFNγ-induced NO production [27]
 LPS-induced inflammatory response [90]
 LPS-induced vascular permeability [80, 256]
 Zymosan-induced inflammation [257]
 Carrageenan-induced paw edema [258]
 Inflammatory response of cardiopulmonary bypass [259]
 Type I allergy [26]
 Asthma [63]
Perinatal Disorders  
 Neonatal cerebral hypoxia [260263]
 LPS-induced fetal lung injury [15]
 Preeclampsia [264, 265]
Cancer  
 Growth of tongue carcinoma cells [266]
 Fe-NTA-induced nephrotoxicity and tumor progression [65]
 Radiation-induced thymic lymphoma [267]
 Tumor angiogenesis [268]
 Enhancement of 5-FU antitumor efficacy [269]
Radiation  
 Cardiac damage [270]
 Lung damage [271]
 Testicular damage [272]
 Skin damage [273, 274]
 Germ, hematopoietic and other cell damage [275280]
 Radiation-induced adverse effects [281]
 Radiation-induced immune dysfunction [282]
Intoxication  
 Carbon monoxide [283286]
 Sevoflurane [287, 288]
 Doxorubicin-induced heart failure [289]
 Melamine-induced urinary stone [290]
 Chlorpyrifos-induced neurotoxicity [291]
Transplantation  
 Heart [52, 292294]
 Lung [33, 88, 295299]
 Kidney [30, 51]
 Intestine [89, 300, 301]
 Pancreas [302]
 Osteochondral grafts [303]
 Acute GVHD [304, 305]
Resuscitation  
 Cardiac arrest [306, 307]
 Hemorrhagic shock [75, 308, 309]
Dialysis  
 Hemodialysis [310313]
 Peritoneal dialysis [314, 315]
Others  
 Lifespan extension [316]
 Sperm motility [317]
 Decompression sickness [318]
 Genotoxicity and mutagenicity [319]
Plant  
 Root organogenesis [91, 320]
 Salt tolerance [321, 322]
 Postharvest ripening [323]
 Stomatal closure [324]
 Radish sprout tolerance to UVA [325]
 High light stress [326]
 Phytohormone signaling and stress responses [327]
 Tolerance to paraquat-induced oxidative stress [328]
 Cadmium toxicity [329, 330]
 Mercury toxicity [331]