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Table 2 Disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants (321 original articles published in English) for which the effects of hydrogen have been reported from 2007 to June 2015

From: Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

Diseases and conditions

References

Brain

 

Cerebrovascular diseases (CVD)

 

 Cerebral I/R injury

[1, 10, 56, 83, 94, 99–109]

 Hypertensive stroke

[110]

 Brain injury secondary to intracerebral hemorrhage

[28]

 Subarachnoid hemorrhage

[48, 61, 66, 73, 111–113]

Brain injury other than CVD

 

 Traumatic brain injury

[114–118]

 Deep hypothermic circulatory arrest-induced brain damage

[57]

Neurodegenerative diseases

 

 Parkinson’s disease

[11, 95–97, 119]

 Alzheimer’s disease

[43, 120]

Others

 

 Restraint-induced dementia

[121]

 Senile dementia in senescence-accelerated mice

[122]

 LPS-induced neuroinflammation

[81, 123]

 Oxidative stress-induced neuronal cell damage

[124, 125]

Spinal Cord and peripheral nerve

 

 Spinal cord I/R injury

[126, 127]

 Spinal cord injury

[77, 128]

 Neuropathic pain

[39, 92, 129, 130]

 Hyperalgesia

[79, 131, 132]

Eye

 

 Retinal I/R injury

[133, 134]

 Diabetic retinopathy

[135, 136]

 Hyperoxia-induced retinopathy

[137]

 Light-induced retinopathy

[138, 139]

 Glutamine-induced retinopathy

[50]

 S-nitroso-N-acetylpenicillamine-induced retinopathy

[140]

 Optic nerve crush

[141]

 Selenite-induced cataract

[142]

 Corneal alkali-burn

[55]

 Anti-inflammatory effects on LPS-activated retinal microglia cells

[64]

Ear

 

 Hearing loss

[143–148]

 Cisplatin-induced ototoxicity

[149, 150]

 Ouabain-induced ototoxicity

[151]

Oral Cavity

 

 Periodontitis

[32]

 Periodontal oxidative damage

[152]

Lung

 

 Lung I/R injury

[153, 154]

 Oxygen-induced lung injury

[82, 155, 156]

 Ventilation-induced lung injury

[53, 157]

 LPS-induced acute lung injury

[13, 14, 16, 158]

 Intestinal I/R-induced lung injury

[159]

 Burn-induced lung injury

[160]

 Paraquat-induced lung injury

[161, 162]

 igarette smoking lung injury

[163]

 Smoke inhalation lung injury

[74]

 Pulmonary hypertension

[78, 164]

Heart

 

 Myocardial infarction and I/R injury

[17–24, 84]

 Diabetic cardiomyopathy

[40]

 Sleep apnea-induced left ventricular remodeling

[165, 166]

 Ventricular hypertrophy

[167]

Stomach

 

 Stress-induced gastric ulceration

[38]

 Aspirin-induced gastric ulceration

[168, 169]

Intestine

 

 Intestinal I/R injury

[170, 171]

 Ulcerative colitis

[172, 173]

 Colon inflammation

[174]

 Sepsis-induced intestinal injury

[87]

 Necrotizing enterocolitis

[175]

Liver

 

 Liver I/R injury

[71, 98, 176–178]

 Chronic hepatitis B

[179]

 Nonalcoholic steatohepatitis

[180]

 Liver injury induced by massive hepatectomy

[67, 93, 181]

 Liver injury induced by obstructive jaundice

[31]

 Liver injury induced by endotoxin

[35]

 Liver injury induced by acetaminophen

[47]

 Liver injury induced by carbon tetrachloride

[42]

 Liver injury induced by concanavalin A

[182]

 Liver cirrhosis

[183]

 Liver fibrosis

[184]

Pancreas

 

 Acute pancreatitis

[76, 185–187]

Peritoneum

 

 Acute peritonitis

[68]

Kidney

 

 Renal I/R injury

[188–190]

 Acute renal injury

[37, 72, 191–194]

 Hypertensive renal injury

[69]

 Cisplatin-induced nephropathy

[195–197]

 Gentamicin-induced nephrotoxicity

[198]

 Inhibition of AGEs production

[199]

 Renal calcium deposition

[200]

Bladder

 

 Interstitial cystitis

[201]

Reproductive organ

 

 Testicular I/R injury

[202, 203]

 Erectile dysfunction

[204]

 Nicotine-induced testicular oxidative stress

[205]

 Cigarette smoke-induced testicular damage

[206]

Skin

 

 I/R injury

[46, 207]

 UV-induced skin injury

[45, 208–211]

 Acute erythematous skin disease

[212]

 Atopic dermatitis

[213, 214]

 Psoriasis

[215]

 Pressure ulcer

[216]

 Burn

[49, 70]

 Arsenic toxicity

[217]

Bone and Joint

 

 Rheumatoid arthritis

[218, 219]

 Osteoporosis

[36, 62]

 Bone loss induced by microgravity

[34]

 TNFα-induced osteoblast injury

[220]

 NO-induced cartilage toxicity

[221]

Skeletal Muscle and soft tissue

 

 I/R injury in skeletal muscle

[222]

 Inflammatory and mitochondrial myopathies

[223]

 Muscle fatigue

[224]

 Sports-related soft tissue injury

[225]

Blood vessel

 

 Atherosclerosis

[58, 59, 85, 226, 227]

 AGEs-induced blood vessel damage

[228]

 Neointimal hyperplasia

[29]

 Hyperplasia in arterialized vein graft

[229]

 Vascular dysfunction

[60]

 Vascular endothelial function

[230]

Blood and Bone Marrow

 

 Aplastic anemia

[231]

 Maintenance of multipotential stroma/mesenchymal stem cells

[232]

 Neutrophil function

[233]

 Inhibition of collagen-induced platelet aggregation

[234]

 Improvement of blood fluidity

[235]

Metabolism

 

 Diabetes mellitus

[236–241]

 Hyperlipidemia

[44, 242–244]

 Metabolic syndrome

[245–247]

 Metabolic process-related gene expression

[248]

 Oxidized low density lipoprotein-induced cell toxicity

[54]

 Serum alkalinization

[249]

 Exercise-induced metabolic acidosis

[250]

Inflammation/Allergy

 

 Sepsis

[41, 86, 251–255]

 LPS/IFNγ-induced NO production

[27]

 LPS-induced inflammatory response

[90]

 LPS-induced vascular permeability

[80, 256]

 Zymosan-induced inflammation

[257]

 Carrageenan-induced paw edema

[258]

 Inflammatory response of cardiopulmonary bypass

[259]

 Type I allergy

[26]

 Asthma

[63]

Perinatal Disorders

 

 Neonatal cerebral hypoxia

[260–263]

 LPS-induced fetal lung injury

[15]

 Preeclampsia

[264, 265]

Cancer

 

 Growth of tongue carcinoma cells

[266]

 Fe-NTA-induced nephrotoxicity and tumor progression

[65]

 Radiation-induced thymic lymphoma

[267]

 Tumor angiogenesis

[268]

 Enhancement of 5-FU antitumor efficacy

[269]

Radiation

 

 Cardiac damage

[270]

 Lung damage

[271]

 Testicular damage

[272]

 Skin damage

[273, 274]

 Germ, hematopoietic and other cell damage

[275–280]

 Radiation-induced adverse effects

[281]

 Radiation-induced immune dysfunction

[282]

Intoxication

 

 Carbon monoxide

[283–286]

 Sevoflurane

[287, 288]

 Doxorubicin-induced heart failure

[289]

 Melamine-induced urinary stone

[290]

 Chlorpyrifos-induced neurotoxicity

[291]

Transplantation

 

 Heart

[52, 292–294]

 Lung

[33, 88, 295–299]

 Kidney

[30, 51]

 Intestine

[89, 300, 301]

 Pancreas

[302]

 Osteochondral grafts

[303]

 Acute GVHD

[304, 305]

Resuscitation

 

 Cardiac arrest

[306, 307]

 Hemorrhagic shock

[75, 308, 309]

Dialysis

 

 Hemodialysis

[310–313]

 Peritoneal dialysis

[314, 315]

Others

 

 Lifespan extension

[316]

 Sperm motility

[317]

 Decompression sickness

[318]

 Genotoxicity and mutagenicity

[319]

Plant

 

 Root organogenesis

[91, 320]

 Salt tolerance

[321, 322]

 Postharvest ripening

[323]

 Stomatal closure

[324]

 Radish sprout tolerance to UVA

[325]

 High light stress

[326]

 Phytohormone signaling and stress responses

[327]

 Tolerance to paraquat-induced oxidative stress

[328]

 Cadmium toxicity

[329, 330]

 Mercury toxicity

[331]