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  1. Content type: Review

    Hydrogen sulfide is a novel mediator with the unique properties of a gasotransmitter and many and varied physiological effects. Included in these effects are a number of cardiovascular effects that are proving...

    Authors: Eloise Streeter, Hooi H Ng and Joanne L Hart

    Citation: Medical Gas Research 2013 3:9

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  2. Content type: Research

    Hyperbaric oxygen therapy (HBOT), referring to the medical use of oxygen at a level higher than atmospheric pressure, exerts neuroprotective effects after ischemic stroke via various mechanisms. It has been de...

    Authors: Jun Mu, Robert P Ostrowski, Paul R Krafft, Jiping Tang and John H Zhang

    Citation: Medical Gas Research 2013 3:8

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  3. Content type: Editorial

    The articles contained in this review series exemplify the diverse applications and succinct biological relevance of this simple gas. Articles summarizing the important effects of carbon monoxide in preventing...

    Authors: Leo E Otterbein

    Citation: Medical Gas Research 2013 3:7

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  4. Content type: Research

    There is accumulating evidence that obesity is closely associated with an impaired free fatty acid metabolism as well as with insulin resistance and inflammation. Excessive fatty acid uptake mediated by fatty ...

    Authors: Akio Iio, Mikako Ito, Tomohiro Itoh, Riyako Terazawa, Yasunori Fujita, Yoshinori Nozawa, Ikuroh Ohsawa, Kinji Ohno and Masafumi Ito

    Citation: Medical Gas Research 2013 3:6

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  5. Content type: Review

    Xenon is a medical gas capable of establishing neuroprotection, inducing anesthesia as well as serving in modern laser technology and nuclear medicine as a contrast agent. In spite of its high cost, its lack o...

    Authors: Ecem Esencan, Simge Yuksel, Yusuf Berk Tosun, Alexander Robinot, Ihsan Solaroglu and John H Zhang

    Citation: Medical Gas Research 2013 3:4

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  6. Content type: Review

    Xenon is one of noble gases and has been recognized as an anesthetic for more than 50 years. Xenon possesses many of the characteristics of an ideal anesthetic, but it is not widely applied in clinical practic...

    Authors: Wenwu Liu, Ying Liu, Han Chen, Kan Liu, Hengyi Tao and Xuejun Sun

    Citation: Medical Gas Research 2013 3:3

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  7. Content type: Research

    Inhalation of low-density helium/oxygen mixtures has been used both to lower the airway resistance and work of breathing of patients with obstructive lung disease and to transport pharmaceutical aerosols to ob...

    Authors: Andrew R Martin, Ira M Katz, Yonatan Lipsitz, Karine Terzibachi, Georges Caillibotte and Joëlle Texereau

    Citation: Medical Gas Research 2012 2:31

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  8. Content type: Research

    Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in t...

    Authors: Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, Yuji Naritomi, Hiroshi Hara and Tetsuhiko Nagao

    Citation: Medical Gas Research 2012 2:27

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  9. Content type: Research

    Local pulmonary and systemic infections can lead to acute lung injury (ALI). The resulting lung damage can evoke lung failure and multiple organ dysfunction associated with increased mortality. Hydrogen sulfid...

    Authors: Simone Faller, Kornelia K Zimmermann, Karl M Strosing, Helen Engelstaedter, Hartmut Buerkle, René Schmidt, Sashko G Spassov and Alexander Hoetzel

    Citation: Medical Gas Research 2012 2:26

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  10. Content type: Commentary

    Methane is an attractive fuel. Biologically, methanogens in the colon can use carbon dioxide and hydrogen to produce methane as a by-product. It was previously considered that methane is not utilized by humans...

    Authors: Wenwu Liu, Dong Wang, Hengyi Tao and XueJun Sun

    Citation: Medical Gas Research 2012 2:25

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  11. Content type: Research

    HyperBaric Oxygen (HBO) therapy involves exposure to pure oxygen in a pressurized room, and it is an already well-established treatment for various conditions, including those originated by serious infections....

    Authors: Vincenzo Zanon, Lucia Rossi, Elena Castellani, Enrico Mario Camporesi, Giorgio Palù and Gerardo Bosco

    Citation: Medical Gas Research 2012 2:24

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  12. Content type: Research

    The pathogenesis of inflammatory bowel disease (IBD) is complex, and an effective therapeutic strategy has yet to be established. Recently, carbon monoxide (CO) has been reported to be capable of reducing infl...

    Authors: Tomohisa Takagi, Yuji Naito, Kazuhiko Uchiyama, Toshimitsu Okuda, Takahiro Suzuki, Hisato Tsuboi, Katsura Mizushima, Osamu Handa, Nobuaki Yagi, Hiroshi Ichikawa and Toshikazu Yoshikawa

    Citation: Medical Gas Research 2012 2:23

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  13. Content type: Review

    This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage. Cardiac as wel...

    Authors: Nicole R Van Allen, Paul R Krafft, Arthur S Leitzke, Richard L Applegate II, Jiping Tang and John H Zhang

    Citation: Medical Gas Research 2012 2:22

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  14. Content type: Case report

    In animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, ...

    Authors: Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Masaki Sakamoto, Yohei Kudo, Kumi Kaneko, Atsunori Nakao and Takashi Imaoka

    Citation: Medical Gas Research 2012 2:21

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  15. Content type: Research

    The inhalation anesthetic isoflurane has been shown to open the mitochondrial permeability transition pore (mPTP) and induce caspase activation and apoptosis, which may lead to learning and memory impairment. ...

    Authors: Yiying Zhang, Yuanlin Dong, Zhipeng Xu and Zhongcong Xie

    Citation: Medical Gas Research 2012 2:20

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  16. Content type: Research

    Reactive oxygen species (ROS) production induced by α,β-dicarbonyl compounds and advanced glycation end products causes renal dysfunction in patients with type 2 diabetes and metabolic syndrome. Hydrogen-rich ...

    Authors: Masanori Katakura, Michio Hashimoto, Yoko Tanabe and Osamu Shido

    Citation: Medical Gas Research 2012 2:18

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  17. Content type: Letter to the Editor

    Many studies have shown that hydrogen can play important roles on the antioxidant, anti-inflammatory and other protective effects. Ohsawa et al have proved that hydrogen can electively and directly scavenge hy...

    Authors: Penghui Shi, Wancang Sun and Pengzhong Shi

    Citation: Medical Gas Research 2012 2:17

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  18. Content type: Review

    Traditionally, hyperbaric oxygen treatment (HBOT) is indicated in several clinical disorders include decompression sickness, healing of problem wounds and arterial gas embolism. However, some investigators hav...

    Authors: Daniel A Rossignol, James J Bradstreet, Kyle Van Dyke, Cindy Schneider, Stuart H Freedenfeld, Nancy O’Hara, Stephanie Cave, Julie A Buckley, Elizabeth A Mumper and Richard E Frye

    Citation: Medical Gas Research 2012 2:16

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  19. Content type: Case report

    We have treated 4 patients of acute erythematous skin diseases with fever and/or pain by H2 enriched intravenous fluid. We also added data from two volunteers for assessing the mode of H2 delivery to the skin for...

    Authors: Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Masaki Sakamoto, Yohei Kudo, Jun Nakazawa, Kumi Kaneko and Atsunori Nakao

    Citation: Medical Gas Research 2012 2:14

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  20. Content type: Research

    Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, and a large amount of hydrogen is produced by bacterial catalysis of lactulose. We previously repo...

    Authors: Mikako Ito, Masaaki Hirayama, Kazuaki Yamai, Sae Goto, Masafumi Ito, Masatoshi Ichihara and Kinji Ohno

    Citation: Medical Gas Research 2012 2:15

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  21. Content type: Research

    Muscle contraction during short intervals of intense exercise causes oxidative stress, which can play a role in the development of overtraining symptoms, including increased fatigue, resulting in muscle microi...

    Authors: Kosuke Aoki, Atsunori Nakao, Takako Adachi, Yasushi Matsui and Shumpei Miyakawa

    Citation: Medical Gas Research 2012 2:12

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  22. Content type: Review

    This article summarized findings of current preclinical studies that implemented hydrogen administration, either in the gas or liquid form, as treatment application for neurological disorders including traumat...

    Authors: Jan M Eckermann, Paul R Krafft, Lorelei Shoemaker, Robert E Lieberson, Steven D Chang and Austin Colohan

    Citation: Medical Gas Research 2012 2:11

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  23. Content type: Commentary

    Volatile anesthetics are one class of the most commonly used drugs. However, the mechanisms for these drugs to induce anesthesia are not fully understood and have been under intensive investigation. Two other ...

    Authors: Zhiyi Zuo

    Citation: Medical Gas Research 2012 2:10

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  24. Content type: Research

    Hemorrhagic transformation (HT) can be a devastating complication of ischemic stroke. Hyperbaric oxygen preconditioning (HBO-PC) has been shown to improve blood-brain barrier (BBB) permeability in stroke model...

    Authors: Yoshiteru Soejima, Robert P Ostrowski, Anatol Manaenko, Mutsumi Fujii, Jiping Tang and John H Zhang

    Citation: Medical Gas Research 2012 2:9

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  25. Content type: Review

    Radiation exposure to astronauts could be a significant obstacle for long duration manned space exploration because of current uncertainties regarding the extent of biological effects. Furthermore, concepts fo...

    Authors: Michael P Schoenfeld, Rafat R Ansari, Atsunori Nakao and David Wink

    Citation: Medical Gas Research 2012 2:8

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  26. Content type: Research

    Voxel-based algorithms using acute multiparametric-MRI data have been shown to accurately predict tissue outcome after stroke. We explored the potential of MRI-based predictive algorithms to objectively assess...

    Authors: Ona Wu, Thomas Benner, Luca Roccatagliata, Mingwang Zhu, Pamela W Schaefer, Alma Gregory Sorensen and Aneesh B Singhal

    Citation: Medical Gas Research 2012 2:5

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  27. Content type: Research

    Heme Oxygenase-1 (HO-1) has been shown to play a pivotal role in pregnancy outcome and its ablation leads to abnormal placentation, intrauterine fetal growth restriction (IUGR) and subsequent intrauterine feta...

    Authors: Tarek El-Mousleh, Pablo A Casalis, Ivonne Wollenberg, Maria L Zenclussen, Hans D Volk, Stefanie Langwisch, Federico Jensen and Ana C Zenclussen

    Citation: Medical Gas Research 2012 2:4

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  28. Content type: Letter to the Editor

    Lactulose, a synthetic sugar not able to be digested and absorbed by human beings, is widely used to treat constipation and hepatic encephalopathy clinically. Through fermentation by the bacteria in the gastro...

    Authors: Xiao Chen, Xiao Zhai, Zhimin Kang and Xuejun Sun

    Citation: Medical Gas Research 2012 2:3

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  29. Content type: Short communication

    In ischemic stroke, blood-brain barrier (BBB) regulations, typically involving matrix metalloproteinases (MMPs) and inhibitors (TIMPs) as mediators, became interesting since tissue plasminogen activator (tPA)-...

    Authors: Dominik Michalski, Carsten Hobohm, Christopher Weise, Johann Pelz, Marita Heindl, Manja Kamprad, Johannes Kacza and Wolfgang Härtig

    Citation: Medical Gas Research 2012 2:2

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  30. Content type: Study protocol

    A simple titration (oxidimetry) method using a methylene blue-platinum colloid reagent is effective in determining the concentration of hydrogen gas in an aqueous solution. The method performs as effectively a...

    Authors: Tomoki Seo, Ryosuke Kurokawa and Bunpei Sato

    Citation: Medical Gas Research 2012 2:1

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  31. Content type: Short communication

    The property values of therapeutic gas mixtures are important in designing devices, defining delivery parameters, and in understanding the therapeutic effects. In the medical related literature the vast majori...

    Authors: Ira Katz, Georges Caillibotte, Andrew R Martin and Philippe Arpentinier

    Citation: Medical Gas Research 2011 1:28

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  32. Content type: Research

    Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative st...

    Authors: Michio Hashimoto, Masanori Katakura, Toru Nabika, Yoko Tanabe, Shahdat Hossain, Satoru Tsuchikura and Osamu Shido

    Citation: Medical Gas Research 2011 1:26

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  33. Content type: Research

    Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in ...

    Authors: Mikako Ito, Tohru Ibi, Ko Sahashi, Masashi Ichihara, Masafumi Ito and Kinji Ohno

    Citation: Medical Gas Research 2011 1:24

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  34. Content type: Research

    Normobaric hyperoxia (NBO) has been shown to be neuro- and vaso-protective during ischemic stroke. However, the underlying mechanisms remain to be fully elucidated. Activation of NADPH oxidase critically contr...

    Authors: Wenlan Liu, Qingquan Chen, Jie Liu and Ke Jian Liu

    Citation: Medical Gas Research 2011 1:22

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