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  1. Review

    A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I – Protection via specific pathways)

    Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous ci...

    Dustin B Mangus, Lei Huang, Patricia M Applegate, Jason W Gatling, John Zhang and Richard L Applegate II

    Medical Gas Research 2014 4:9

    Published on: 1 May 2014

  2. Commentary

    Hyperbaric oxygen therapy for chronic post-concussive syndrome

    In this editorial, the value of hyperbaric oxygen therapy in the management of chronic post-concussive syndrome following mild traumatic brain injury is discussed.

    Matthew C Davis, Mohammadali M Shoja, Shane R Tubbs and Christoph J Griessenauer

    Medical Gas Research 2014 4:8

    Published on: 9 April 2014

  3. Research

    Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: a randomized controlled trial

    As life expectancy increases, more patients ≥65 years undergo general anesthesia. Anesthetic agents may contribute to postoperative cognitive dysfunction, and incidence may differ with anesthetic agents or int...

    Minhthy Meineke, Richard L Applegate II, Thomas Rasmussen, Donald Anderson, Sherif Azer, Ali Mehdizadeh, Amy Kim and Martin Allard

    Medical Gas Research 2014 4:6

    Published on: 25 March 2014

  4. Research

    The potential dual effects of sevoflurane on AKT/GSK3β signaling pathway

    Anesthesia with multiple exposures of commonly used inhalation anesthetic sevoflurane induces neuroinflammation and cognitive impairment in young mice, but anesthesia with a single exposure to sevoflurane does...

    Lei Zhang, Jie Zhang, Yuanlin Dong, Celeste A Swain, Yiying Zhang and Zhongcong Xie

    Medical Gas Research 2014 4:5

    Published on: 3 March 2014

  5. Research

    In vitroActivation of heme oxygenase-2 by menadione and its analogs

    Previously, we reported that menadione activated rat, native heme oxygenase-2 (HO-2) and human recombinant heme oxygenase-2 selectively; it did not activate spleen, microsomal heme oxygenase-1. The purpose of ...

    Dragic Vukomanovic, Mona N Rahman, Yaroslav Bilokin, Andriy G Golub, James F Brien, Walter A Szarek, Zongchao Jia and Kanji Nakatsu

    Medical Gas Research 2014 4:4

    Published on: 18 February 2014

  6. Review

    Argon gas: a potential neuroprotectant and promising medical therapy

    Argon is a noble gas element that has demonstrated narcotic and protective abilities that may prove useful in the medical field. The earliest records of argon gas have exposed its ability to exhibit narcotic s...

    Derek S Nowrangi, Jiping Tang and John H Zhang

    Medical Gas Research 2014 4:3

    Published on: 17 February 2014

  7. Review

    Adverse effect of inhalational anesthetics on the developing brain

    We did a PubMed search and summarized studies on the potential adverse effect of anesthetics especially neurotoxicity in the developing brain, so named anesthesia-induced developmental neurotoxicity. Even thou...

    Mike Wang, John H Zhang and Richard L Applegate II

    Medical Gas Research 2014 4:2

    Published on: 14 February 2014

  8. Research

    Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water

    Recent studies have revealed the biological effects of H2 in suppressing organ injuries due to acute inflammation and oxidative stress. Dahl salt-sensitive (SS) rats naturally develop elevated blood pressure (BP)...

    Wan-Jun Zhu, Masaaki Nakayama, Takefumi Mori, Kiyotaka Hao, Hiroyuki Terawaki, Junichiro Katoh, Shigeru Kabayama and Sadayoshi Ito

    Medical Gas Research 2013 3:26

    Published on: 2 December 2013

  9. Commentary

    Hypocapnia as a poor prognostic factor in aneurysmal subarachnoid hemorrhage

    In this editorial, the issues of hypocapnia and its relation to symptomatic vasospasm, prognosis, and outcome among patients with aneurysmal subarachnoid hemorrhage is discussed. Potential directions for futur...

    Paul Foreman, Christoph J Griessenauer, Mohammadali M Shoja and R Shane Tubbs

    Medical Gas Research 2013 3:25

    Published on: 25 November 2013

  10. Research

    A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis

    Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents for arthritic patients, although gastric effects limit their long-term use. Considering the reported gastric safety of hydr...

    Eduardo Ekundi-Valentim, Filiphe PN Mesquita, Karen T Santos, Marco A Vieira de Paula, Juliana Florenzano, Cristiane I Zanoni, Leandro Rodrigues, Gilberto de Nucci, Simone A Teixeira, Heloisa HA Ferreira, John L Wallace, Soraia KP Costa and Marcelo N Muscará

    Medical Gas Research 2013 3:24

    Published on: 16 November 2013

  11. Review

    Hypercapnia: is it protective in lung injury?

    Hypercapnic acidosis has been regarded as a tolerated side effect of protective lung ventilation strategies. Various in vivo and ex vivo animal studies have shown beneficial effects in acute lung injury settin...

    Alexander F Bautista and Ozan Akca

    Medical Gas Research 2013 3:23

    Published on: 11 November 2013

  12. Review

    Bustling argon: biological effect

    Argon is a noble gas in group 18 of the periodic table. Certificated to exist in air atmosphere merely one century ago, discovery of argon shows interesting stories of researching and exploring. It was assumed...

    Zhouheng Ye, Rongjia Zhang and Xuejun Sun

    Medical Gas Research 2013 3:22

    Published on: 3 October 2013

  13. Research

    Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro

    Pressure ulcer (PU) is common in immobile elderly patients, and there are some research works to investigate a preventive and curative method, but not to find sufficient effectiveness. The aim of this study is...

    Qiang Li, Shinya Kato, Daigo Matsuoka, Hiroshi Tanaka and Nobuhiko Miwa

    Medical Gas Research 2013 3:20

    Published on: 10 September 2013

  14. Review

    The role of helium gas in medicine

    The noble gas helium has many applications owing to its distinct physical and chemical characteristics, namely: its low density, low solubility, and high thermal conductivity. Chiefly, the abundance of studies...

    Carlos J Berganza and John H Zhang

    Medical Gas Research 2013 3:18

    Published on: 4 August 2013

  15. Review

    Research of medical gases in Poland

    Research of medical gases is well established in Poland and has been marked with the foundation of several professional societies. Numerous academic centers including those dealing with hyperbaric and diving m...

    Robert P Ostrowski and Emanuela B Pucko

    Medical Gas Research 2013 3:17

    Published on: 2 August 2013

  16. Study protocol

    Does hyperbaric oxygen therapy have the potential to improve salivary gland function in irradiated head and neck cancer patients?

    Following radiotherapy, many patients with osteoradionecrosis suffer from xerostomia, thereby decreasing their quality of life. Patients can develop problems with speech, eating, increased dental caries, dysph...

    Tiffany Hadley, Cassaundra Song, Lauren Wells, Jennifer Lehnhardt, Marcy Wells Rogers, Jeffery Anderson, Michael Terry, Brian Novy and Takkin Lo

    Medical Gas Research 2013 3:15

    Published on: 2 July 2013

  17. Research

    Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity

    Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of...

    Hiroyuki Terawaki, Yoshimitsu Hayashi, Wan-Jun Zhu, Yukie Matsuyama, Tomoyoshi Terada, Shigeru Kabayama, Tsuyoshi Watanabe, Seiichi Era, Bunpei Sato and Masaaki Nakayama

    Medical Gas Research 2013 3:14

    Published on: 1 July 2013

  18. Case report

    Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies

    Most of the results regarding hydrogen (H2) therapy for acute cerebral ischemia are derived from in vitro studies and animal experiments, with only a few obtained from human trials with a limited number of subjec...

    Kimihiro Nagatani, Hiroshi Nawashiro, Satoru Takeuchi, Satoshi Tomura, Naoki Otani, Hideo Osada, Kojiro Wada, Hiroshi Katoh, Nobusuke Tsuzuki and Kentaro Mori

    Medical Gas Research 2013 3:13

    Published on: 25 June 2013

  19. Research

    Xenon consumption during general surgery: a retrospective observational study

    High costs still limits the widespread use of xenon in the clinical practice. Therefore, we evaluated xenon consumption of different delivery modes during general surgery.

    Christian Stoppe, Achim Rimek, Rolf Rossaint, Steffen Rex, Ana Stevanovic, Gereon Schälte, Astrid Fahlenkamp, Michael Czaplik, Christian S Bruells, Christian Daviet and Mark Coburn

    Medical Gas Research 2013 3:12

    Published on: 11 June 2013

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