The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

Ohta, Shigeo; Nakao, Atsunori; Ohno, Kinji

doi:10.1186/2045-9912-1-10

Medical Gas Research

Table 2 Thirty-eight diseases and physiological states for which hydrogen effects are reported

From: The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

Disease/Physiology	Species	Source of H₂	Reference
Brain
Cerebral infarction	rodent	gas	[1]
Superoxide in brain	rodent	water	[6]
Neonatal brain hypoxia	rodent	gas	[2, 7]
	rodent	saline	[8]
	pig	gas	[9]
Restraint-induced dementia	rodent	water	[10]
Alzheimer's disease	rodent	saline	[11]
Senile dementia	rodent	water	[12]
Parkinson's disease	rodent	water	[13, 14]
Hemorrhagic cerebral infarction	rodent	gas	[15]
Traumatic brain injury	rodent	gas	[16]
Spinal cord
Spinal cord injury	rodent	saline	[17]
Eye
Glaucoma	rodent	eye drop	[18]
Corneal alkali-burn	rodent	eye drop	[19]
Ear
Hearing disturbance	rodent	medium	[20]
	rodent	gas	[21]
	rodent	water	[22]
Lung
Lung cancer	Cells	medium	[23]
Oxygen-induced lung injury	rodent	saline	[24, 25]
Lung transplantation	rodent	gas	[26]
Heart
Myocardial infarction	rodent	gas	[27]
	rodent	saline	[28]
Heart transplantation	rodent	gas	[29]
Irradiation-induced heart injury	rodent	water	[30]
Liver
Hepatic ischemia	rodent	gas	[31]
Hepatitis	rodent	bacteria	[5]
Obstructive jaundice	rodent	saline	[32]
Kidney
Cisplatin nephropathy	rodent	gas, water	[33]
	rodent	water	[34]
Hemodialysis	human	dialysis	[35, 36]
Kidney transplantation	rodent	water	[4]
Pancreas
Acute pancreatitis	rodent	saline	[37]
Intestine
Intestinal graft	rodent	gas	[3]
	rodent	saline	[38, 39]
Ulcerative colitis	rodent	gas	[40]
Blood vessel
Atherosclerosis	rodent	water	[41]
Metabolism
Diabetes mellitus type 2	human	water	[42]
Metabolic syndrome	human	water	[43]
Obesity/Diabetes	rodent	water	[44]
Cancer
Tongue carcinoma	cells	medium	[45]
Inflammation and allergy
Allergy type I	rodent	water	[46]
Sepsis	rodent	gas	[47]
Zymosan-induced inflammation	rodent	gas	[47]
Others
Multipotent stromal cells	cells	gas	[48]
Radiation injury	cells	medium	[49, 50]

Although the observations are not directly relevant to diseases, Turmeric [51] and acarbose [52] increase hydrogen production by intestinal bacteria in humans.

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ISSN: 2045-9912

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