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  1. Review

    Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

    Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. M...

    Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama and Kinji Ohno

    Medical Gas Research 2015 5:12

    Published on: 19 October 2015

  2. Research

    Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats

    This study investigated the therapeutic effects of hyperbaric oxygen in experimental acute distal colitis focusing on its effect on the production of pro-inflammatory cytokines, nitric oxide and hypoxia-induci...

    Rogério S Parra, Alexandre H Lopes, Eleonora U Carreira, Marley R Feitosa, Fernando Q Cunha, Sérgio B Garcia, Thiago M Cunha, José J R da Rocha and Omar Féres

    Medical Gas Research 2015 5:6

    Published on: 16 April 2015

  3. Research

    The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

    In experimental periodontitis, non-steroidal antiinflammatory drugs (NSAIDs) effectively inhibit the resultant alveolar bone loss. However, their deleterious gastric effects, observed in both animals and human...

    Bruno Schneider Herrera, Leila Santana Coimbra, Agatha Ribeiro da Silva, Simone Aparecida Teixeira, Soraia Katia Pereira Costa, John Lawrence Wallace, Luis Carlos Spolidorio and Marcelo Nicolas Muscara

    Medical Gas Research 2015 5:4

    Published on: 27 February 2015

  4. Review

    Hyperbaric oxygen therapy in China

    Hyperbaric oxygen therapy (HBOT) is defined as a treatment in which a patient intermittently breathes 100% oxygen while the treatment chamber is pressurized to a pressure greater than sea level (1.0 atmosphere...

    Ling Yan, Ting Liang and Oumei Cheng

    Medical Gas Research 2015 5:3

    Published on: 18 February 2015

  5. Research

    Stimulation of human damaged sperm motility with hydrogen molecule

    Sperm motility is a critical factor in male fertility. Low motility can be caused by a variety factors including abnormal spermatogenesis, oxidative damage, or depletion of intracellular ATP. Recent findings i...

    Kumiko Nakata, Naoki Yamashita, Yoshihiro Noda and Ikuroh Ohsawa

    Medical Gas Research 2015 5:2

    Published on: 10 January 2015

  6. Research

    Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential

    Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Hydrogen sulfide (H2S) plays an important role in physiology and pathophysiology of liver. However, whether exogenous H2S...

    Dongdong Wu, Nairui Zheng, Kunqing Qi, Huijun Cheng, Ziqiang Sun, Biao Gao, Youjing Zhang, Wuyan Pang, Chaoshen Huangfu, Shaoping Ji, Mengzhou Xue, Ailing Ji and Yanzhang Li

    Medical Gas Research 2015 5:1

    Published on: 10 January 2015

  7. Research

    Argon prevents the development of locomotor sensitization to amphetamine and amphetamine-induced changes in mu opioid receptor in the nucleus accumbens

    Systemic administration of γ-amino-butyric acid type A (GABA-A) and benzodiazepine receptor agonists has been reported to block the development of locomotor sensitization to amphetamine. Here, we investigated ...

    Hélène N David, Martine Dhilly, Géraldine Poisnel, Mickael Degoulet, Cédric Meckler, Nicolas Vallée, Jean-Éric Blatteau, Jean-Jacques Risso, Marc Lemaire, Danièle Debruyne and Jacques H Abraini

    Medical Gas Research 2014 4:21

    Published on: 29 December 2014

  8. Research

    Hydrogen sulfide provides cardioprotection against myocardial/ischemia reperfusion injury in the diabetic state through the activation of the RISK pathway

    Coronary artery disease remains the principal cause of death in patients with diabetes mellitus. Diabetic mice display exacerbated injury following myocardial ischemia-reperfusion (MI/R) and are resistant to m...

    Jonathan P Lambert, Chad K Nicholson, Hena Amin, Sana Amin and John W Calvert

    Medical Gas Research 2014 4:20

    Published on: 12 December 2014

  9. Review

    Review and prospect of the biomedical effects of hydrogen

    Hydrogen, the simplest gas in nature, was recently reported as a therapeutic antioxidant through selectively reducing cytotoxic oxygen radicals. Though hundreds of studies on curative effects of hydrogen were ...

    Xiao Zhai, Xiao Chen, Shigeo Ohta and Xuejun Sun

    Medical Gas Research 2014 4:19

    Published on: 29 November 2014

  10. Research

    Supplemental oxygen delivery to suspected stroke patients in pre hospital and emergency department settings

    Recent data suggests that high-flow oxygen started promptly after stroke symptom onset salvages ischemic brain tissue. We investigated the consistency of oxygen delivery to suspected stroke patients in the pre...

    Yu-Feng Yvonne Chan, Maya Katz, Ari Moskowitz, Steven R Levine, Lynne D Richardson, Stanley Tuhrim, Kevin Chason, Kelly Barsan- Silverman and Aneesh Singhal

    Medical Gas Research 2014 4:16

    Published on: 27 October 2014

  11. Review

    Can carbon monoxide-poisoned victims be organ donors?

    The increasing demand for organ allografts to treat end-stage organ failure has driven changes in traditional donor criteria. Patients who have succumbed to carbon monoxide (CO) poisoning, a common cause of to...

    Noritomo Fujisaki, Atsunori Nakao, Takaaki Osako, Takeshi Nishimura, Taihei Yamada, Keisuke Kohama, Hiroyuki Sakata, Michiko Ishikawa-Aoyama and Joji Kotani

    Medical Gas Research 2014 4:13

    Published on: 31 July 2014

  12. Research

    Expression analysis following argon treatment in an in vivomodel of transient middle cerebral artery occlusion in rats

    Argon treatment following experimental neurotrauma has been found neuroprotective in an array of in vivo and in vitro models. The inherent cellular and molecular mechanisms are still unknown. We seeked to shed li...

    Astrid V Fahlenkamp, Mark Coburn, Antonio de Prada, Nadine Gereitzig, Cordian Beyer, Hajo Haase, Rolf Rossaint, Jens Gempt and Yu-Mi Ryang

    Medical Gas Research 2014 4:11

    Published on: 6 June 2014

  13. Review

    A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (part II-comprehensive protection)

    Neurocognitive deficits remain a significant source of morbidity in survivors of cardiac arrest. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival fol...

    Lei Huang, Patricia M Applegate, Jason W Gatling, Dustin B Mangus, John Zhang and Richard L Applegate II

    Medical Gas Research 2014 4:10

    Published on: 20 May 2014

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