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  1. Content type: Study protocol

    Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the...

    Authors: Ryosuke Kurokawa, Tomoki Seo, Bunpei Sato, Shin-ichi Hirano and Fumitake Sato

    Citation: Medical Gas Research 2015 5:13

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  2. Content type: Review

    Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. M...

    Authors: Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama and Kinji Ohno

    Citation: Medical Gas Research 2015 5:12

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  3. Content type: Commentary

    Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating...

    Authors: Qin Hu, Anatol Manaenko, Zhenni Guo, Lei Huang, Jiping Tang and John H. Zhang

    Citation: Medical Gas Research 2015 5:10

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  4. Content type: Research

    New gas therapies using inert gases such as xenon and argon are being studied, which would require chronically administered repeating doses. The pharmacokinetics of this type of administration has not been add...

    Authors: Ira Katz, Jacqueline Murdock, Marc Palgen, Jan Pype and Georges Caillibotte

    Citation: Medical Gas Research 2015 5:8

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  5. Content type: Research

    This study investigated the therapeutic effects of hyperbaric oxygen in experimental acute distal colitis focusing on its effect on the production of pro-inflammatory cytokines, nitric oxide and hypoxia-induci...

    Authors: Rogério S Parra, Alexandre H Lopes, Eleonora U Carreira, Marley R Feitosa, Fernando Q Cunha, Sérgio B Garcia, Thiago M Cunha, José J R da Rocha and Omar Féres

    Citation: Medical Gas Research 2015 5:6

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  6. Content type: Research

    Peripheral arterial disease (PAD) affects millions of Americans and leads to critical limb ischemia (CLI) in the most severe cases. Investigators have demonstrated the utility of hydrogen sulfide for restoring...

    Authors: John William Langston and Christopher F Toombs

    Citation: Medical Gas Research 2015 5:5

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  7. Content type: Research

    In experimental periodontitis, non-steroidal antiinflammatory drugs (NSAIDs) effectively inhibit the resultant alveolar bone loss. However, their deleterious gastric effects, observed in both animals and human...

    Authors: Bruno Schneider Herrera, Leila Santana Coimbra, Agatha Ribeiro da Silva, Simone Aparecida Teixeira, Soraia Katia Pereira Costa, John Lawrence Wallace, Luis Carlos Spolidorio and Marcelo Nicolas Muscara

    Citation: Medical Gas Research 2015 5:4

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  8. Content type: Review

    Hyperbaric oxygen therapy (HBOT) is defined as a treatment in which a patient intermittently breathes 100% oxygen while the treatment chamber is pressurized to a pressure greater than sea level (1.0 atmosphere...

    Authors: Ling Yan, Ting Liang and Oumei Cheng

    Citation: Medical Gas Research 2015 5:3

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  9. Content type: Research

    Sperm motility is a critical factor in male fertility. Low motility can be caused by a variety factors including abnormal spermatogenesis, oxidative damage, or depletion of intracellular ATP. Recent findings i...

    Authors: Kumiko Nakata, Naoki Yamashita, Yoshihiro Noda and Ikuroh Ohsawa

    Citation: Medical Gas Research 2015 5:2

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  10. Content type: Research

    Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Hydrogen sulfide (H2S) plays an important role in physiology and pathophysiology of liver. However, whether exogenous H2S...

    Authors: Dongdong Wu, Nairui Zheng, Kunqing Qi, Huijun Cheng, Ziqiang Sun, Biao Gao, Youjing Zhang, Wuyan Pang, Chaoshen Huangfu, Shaoping Ji, Mengzhou Xue, Ailing Ji and Yanzhang Li

    Citation: Medical Gas Research 2015 5:1

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  11. Content type: Research

    Systemic administration of γ-amino-butyric acid type A (GABA-A) and benzodiazepine receptor agonists has been reported to block the development of locomotor sensitization to amphetamine. Here, we investigated ...

    Authors: Hélène N David, Martine Dhilly, Géraldine Poisnel, Mickael Degoulet, Cédric Meckler, Nicolas Vallée, Jean-Éric Blatteau, Jean-Jacques Risso, Marc Lemaire, Danièle Debruyne and Jacques H Abraini

    Citation: Medical Gas Research 2014 4:21

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  12. Content type: Research

    Coronary artery disease remains the principal cause of death in patients with diabetes mellitus. Diabetic mice display exacerbated injury following myocardial ischemia-reperfusion (MI/R) and are resistant to m...

    Authors: Jonathan P Lambert, Chad K Nicholson, Hena Amin, Sana Amin and John W Calvert

    Citation: Medical Gas Research 2014 4:20

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  13. Content type: Review

    Hydrogen, the simplest gas in nature, was recently reported as a therapeutic antioxidant through selectively reducing cytotoxic oxygen radicals. Though hundreds of studies on curative effects of hydrogen were ...

    Authors: Xiao Zhai, Xiao Chen, Shigeo Ohta and Xuejun Sun

    Citation: Medical Gas Research 2014 4:19

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  14. Content type: Review

    Hydrogen is the most abundant chemical element in the Universe, but is seldom regarded as a therapeutic agent. Recent evidence has shown that hydrogen is a potent antioxidative, antiapoptotic and anti-inflamma...

    Authors: Meihua Shen, Hongying Zhang, Congjun Yu, Fan Wang and Xuejun Sun

    Citation: Medical Gas Research 2014 4:17

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  15. Content type: Research

    Recent data suggests that high-flow oxygen started promptly after stroke symptom onset salvages ischemic brain tissue. We investigated the consistency of oxygen delivery to suspected stroke patients in the pre...

    Authors: Yu-Feng Yvonne Chan, Maya Katz, Ari Moskowitz, Steven R Levine, Lynne D Richardson, Stanley Tuhrim, Kevin Chason, Kelly Barsan- Silverman and Aneesh Singhal

    Citation: Medical Gas Research 2014 4:16

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  16. Content type: Research

    Normobaric hyperoxia (NBO) therapy is neuroprotective in acute ischemic stroke. However, how long the NBO should last to obtain optimal outcome is still unclear. Reports show that ischemic penumbra blood suppl...

    Authors: Zhongrui Yuan, Rong Pan, Wenlan Liu and Ke Jian Liu

    Citation: Medical Gas Research 2014 4:14

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  17. Content type: Review

    The increasing demand for organ allografts to treat end-stage organ failure has driven changes in traditional donor criteria. Patients who have succumbed to carbon monoxide (CO) poisoning, a common cause of to...

    Authors: Noritomo Fujisaki, Atsunori Nakao, Takaaki Osako, Takeshi Nishimura, Taihei Yamada, Keisuke Kohama, Hiroyuki Sakata, Michiko Ishikawa-Aoyama and Joji Kotani

    Citation: Medical Gas Research 2014 4:13

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  18. Content type: Research

    Approximately 40% of hemorrhagic stroke survivors develop hydrocephalus. Hyperbaric oxygen (HBO) has been shown to be anti-inflammation following experimental stroke; however, its effect upon post-hemorrhagic ...

    Authors: Qin Hu, Alexander Vakhmjanin, Bo Li, Jiping Tang and John H Zhang

    Citation: Medical Gas Research 2014 4:12

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  19. Content type: Research

    Argon treatment following experimental neurotrauma has been found neuroprotective in an array of in vivo and in vitro models. The inherent cellular and molecular mechanisms are still unknown. We seeked to shed li...

    Authors: Astrid V Fahlenkamp, Mark Coburn, Antonio de Prada, Nadine Gereitzig, Cordian Beyer, Hajo Haase, Rolf Rossaint, Jens Gempt and Yu-Mi Ryang

    Citation: Medical Gas Research 2014 4:11

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  20. Content type: Review

    Neurocognitive deficits remain a significant source of morbidity in survivors of cardiac arrest. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival fol...

    Authors: Lei Huang, Patricia M Applegate, Jason W Gatling, Dustin B Mangus, John Zhang and Richard L Applegate II

    Citation: Medical Gas Research 2014 4:10

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