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Figure 5 | Medical Gas Research

Figure 5

From: Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore

Figure 5

Propofol attenuates isoflurane-induced opening of mPTP in H4-APP cells. A. Flow cytometric analysis shows changes in calcein levels in mitochondria of H4-APP cells stained with calceinAM or calceinAM plus cobalt, which indicate the opening of mPTP. Peak 1: treatment of ionomycin (the positive control of opening of mPTP); peak 2: treatment of isoflurane; peak 3: treatment of isoflurane plus propofol (200 μM). Propofol treatment attenuates isoflurane-induced opening of mPTP, as demonstrated by the position of peak of isoflurane treatment is shifted to the right following propofol treatment.

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Medical Gas Research

ISSN: 2045-9912

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