Example 2 of Predicted Lesion Volume Development. (A)Admission MRI dataset for a 64 year-old male patient imaged at 4.5 hours after stroke symptom onset who was treated with NBO. (B)Corresponding GLM-predicted lesion risk maps for Control and NBO-models at each subsequent time point of imaging, and (C)Overlay map of differences between the two models showing ischemic tissue that is 'potentially salvageable' with NBO therapy. The GLM-predicted lesion volumes are a synthesis of data from the admission MRI only. In this patient, the risk of tissue infarction in DWI/PWI mismatch regions was predicted to increase over time. For clarity, only GLM-predicted lesion risk > 50% are shown overlaid on acute DWI. Note that the amounts of tissue predicted to infarct at all time-points with the Control-models were greater than their NBO-model counterparts, with difference principally in the DWI/PWI mismatch region (arrowheads). In the difference maps (C), the color scale represents infarction risk reduction as a result of NBO-therapy (conversely, larger values represent greater likelihood of infarction if the patient was given Control-treatment).