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Figure 1 | Medical Gas Research

Figure 1

From: Argon prevents the development of locomotor sensitization to amphetamine and amphetamine-induced changes in mu opioid receptor in the nucleus accumbens

Figure 1

Experimental protocol and procedures. Rats (n = 8 per group) were treated daily with either saline solution (1 mL/kg intraperitoneally; IP) or amphetamine (1 mg/mL/kg, IP) from day 1 to day 3. Immediately after injection of saline solution or amphetamine, rats were treated for 3 h with “medicinal” air (composed of 75 vol% nitrogen + 25 vol% oxygen) or argon at 75 vol% (with the remainder being oxygen). Then, after 3 days of withdrawal, behavioral investigations were performed on day 7. Immediately after behavioral testing, the rats’ brain were removed and used to assess the constitutive activity of the mu opioid receptor in the nucleus accumbens.

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Medical Gas Research

ISSN: 2045-9912

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