Figure 2

Micro-computed tomography (μCT) shows that ATB-346 inhibited the increase of the bone area and volume secondary to ligature-induced periodontitis. Bone analysis by μCT in terms of both area (panel A) and volume (panel B) of bone defect. *P < 0.05 and ***P < 0.001 vs. Sham; ^##P < 0.01 and ^###P < 0.001 vs. Vehicle; ^ϕϕP < 0.01 and ^ϕϕϕP < 0.001 vs. Naproxen Panel C: Representative three-dimensional reconstructions of μCT analysis performed on the left hemimandible of the animals subjected to periodontitis. Panel D: μCT images on the sagittal plane of the left hemimandible of the animals depicting the alveolar bone in the interradicular area (n = 6 for each experimental group).