Many more concussions were being reported in the National Football League (NFL) in the 2010 season. A total of 154 concussions, including practices and games, were reported from the start of the preseason through the eighth week of the 2010 regular season.

That is an increase of 21 percent over the 127 concussions during the same span in 2009, and a 34 percent jump from the 115 reported through the eighth week of the 2008 season. (Associated Press, Dec 13, 2010)

This either means better reporting is taking place or the game is getting more violent or some combination of the above. What hasn't changed is a lack of treatment. The lack of appropriate treatment for traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE) is not exclusive to the NFL by any means, but football players both young high school students and old retired NFL veterans are beginning to ask for Hyperbaric Oxygen Therapy (HBOT) to help them recover from their injuries.

Is this a new fad for a therapy looking for a disease, after all if HBOT were efficacious in treating TBI/CTE wouldn't everyone in the medical profession know about it, and wouldn't there be chambers connected to every trauma center?

HBOT has been treating brain injuries as far back as 1963, when it was first found effective in treating carbon monoxide poisoning [1, 2]. Although the misconception that HBOT is only treating carboxy-hemoglobin persists to this day [3]. Brain injuries caused by decompression sickness and arterial gas emboli began being treated by HBOT using Navy Treatment Table six [4, 5]. Delayed treatment (3 months) of an ischemic stroke with HBOT was reported by the US Navy in 1969 [6]. Subsequently successful treatment with HBOT for late treatment of a stroke, diabetic encephalopathy and near-drowning/global anoxia was also reported [7] with the additional evidence of pre and post functional brain imaging (SPECT). The medical literature continues to grow showing HBOT is efficacious in treated old carbon monoxide poisoning (COP) also known as delayed neuropsychiatric syndrome (DNS) of COP [8, 9].

While the historic literature points to HBOT as being efficacious for many conditions, HBOT is an orphan therapy that falls outside of the medical paradigm where drugs and interventions are selectively fed into the standard-of-care/reimbursement complex by corporate interests that control both medical information and clinical practice trends. A therapy that exists outside our dysfunctional medical paradigm tends to be but a footnote that is passed over, buried or ignored completely.

Despite controlled randomized trials demonstrating HBOT's efficacy for treating TBI, ignoring HBOT for treating brain injuries seems to have became codified even though other forms of intervention have fallen short. High quality clinical trials demonstrating the efficacy of HBOT in brain injury eventually get buried or forgotten. Sometimes, those who don't understand the nuance of oxygen dose or timing perform studies and resulting misinterpreted results further marginalize this important tool for treating brain injury [10].

Recent clinical research has demonstrated the efficacy of HBOT (at 1.5 ata) for traumatic brain injury, even when administered years after injury.

While in acute severe TBI, HBOT has been shown to be effective in reducing mortality,[11] Harch et al. demonstrated consistent SPECT brain imaging improvements (showing improved brain blood flow) in chronic TBI patients treated with HBOT 1.5 [12–15]. Since the original work of Drs. Neubauer and Harch, the efficacy of HBOT 1.5 in a chronic stable TBI has been well documented [16, 17]. Patients with abnormal functional brain scans secondary to TBI show consistent improvement after HBOT 1.5.

Recently, Harch et al reported dramatic improvement in a series of 15 patients treated with HBOT 1.5 in a clinical trial of military acquired TBI [18]. Functional brain scans continue to document results for HBOT 1.5 for combat related blast related TBI [19]. In two airmen with pre-injury neuropsychiatric testing and chronic stable TBI symptoms, HBOT 1.5 resulted in resolution of symptoms as well as a return to the pre-injury values for testing [20]. In a randomized controlled trial of stable severe TBI treated with HBOT 1.5 Lin et al demonstrated improvement in the Glasgow Coma Scale [21]. Rockswold has demonstrated improvement in the Glasgow Coma Scale and reduced mortality in acute TBI patients undergoing HBOT with minimal risk [22, 23]. HBOT 1.5 in this group of acute patients appears safe and does not produce oxygen toxicity [24]. Other individual trials also have demonstrated the efficacy of HBOT 1.5 for chronic stable TBI [25]. A 310 patient Chinese trial demonstrated improvement clinically, in neuropsychiatric testing, as well as in functional brain imaging after HBOT 1.5 [26]. In a randomized controlled trial of 21 brain-injured adults, HBOT 1.5 resulted in improved neuropsychiatric testing for the treated group [27].

Presented here are two case reports of football induced TBI/CTE that responded to HBOT.

HBOT is the only non-hormonal treatment approved by the FDA for the repair and regeneration of human tissue. Six of the 13 approved indications are directly related to brain injury and wound repair relevant to treating TBI. The USA Olympic team has now brought in HBOT to treat sports related injuries as part of their armamentarium.

The treatment of traumatic brain injury with hyperbaric oxygen is evolving rapidly. A plethora of cellular studies demonstrate the mechanisms of favorable action of HBOT and animal studies have also been able to add to the clinical rationale and utility for treating a variety of traumatic and ischemic brain injuries. Controlled randomized clinical trials have demonstrated efficacy of HBOT for traumatic brain injury. Therefore, the time has come for this orphan therapy to be adopted and for it to take its place as standard practice for treating both acute and chronic TBI. High profile athletes who are willing to share their response to HBOT for TBI/CTE may accelerate the day when this benign, humanitarian and non-invasive therapy is recognized as a quintessential tool for treating brain injury; after all, oxygen is what the brain fundamentally feeds upon.

Written informed consent was obtained from the patients or their legal guardians for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

KPS is an Adjunct Assistant Professor AT Still University - SOMA.