Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007, 13: 688-694. 10.1038/nm1577.
Article
CAS
PubMed
Google Scholar
Dzau VJ: Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension. 2001, 37: 1047-1052.
Article
CAS
PubMed
Google Scholar
Taniyama Y, Griendling KK: Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension. 2003, 42: 1075-1081. 10.1161/01.HYP.0000100443.09293.4F.
Article
CAS
PubMed
Google Scholar
Ihara Y, Toyokuni S, Uchida K, Odaka H, Tanaka T, Ikeda H, Hiai H, Seino Y, Yamada Y: Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes. 1999, 48: 927-932. 10.2337/diabetes.48.4.927.
Article
CAS
PubMed
Google Scholar
Kurella M, Lo JC, Chertow GM: Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol. 2005, 16: 2134-2140. 10.1681/ASN.2005010106.
Article
PubMed
Google Scholar
Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N: Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010, 46: 140-149. 10.3164/jcbn.09-100.
Article
PubMed Central
PubMed
Google Scholar
Michaelis OEt, Ellwood KC, Judge JM, Schoene NW, Hansen CT: Effect of dietary sucrose on the SHR/N-corpulent rat: a new model for insulin-independent diabetes. Am J Clin Nutr. 1984, 39: 612-618.
CAS
PubMed
Google Scholar
Nangaku M, Izuhara Y, Usuda N, Inagi R, Shibata T, Sugiyama S, Kurokawa K, van Ypersele de Strihou C, Miyata T: In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy. Nephrol Dial Transplant. 2005, 20: 2661-2669. 10.1093/ndt/gfi096.
Article
CAS
PubMed
Google Scholar
Dohi K, Satoh K, Ohtaki H, Shioda S, Miyake Y, Shindo M, Aruga T: Elevated plasma levels of bilirubin in patients with neurotrauma reflect its pathophysiological role in free radical scavenging. In Vivo. 2005, 19: 855-860.
CAS
PubMed
Google Scholar
Uehara Y, Hirawa N, Kawabata Y, Suzuki T, Ohshima N, Oka K, Ikeda T, Goto A, Toyo-oka T, Kizuki K: Long-term infusion of kallikrein attenuates renal injury in Dahl salt-sensitive rats. Hypertension. 1994, 24: 770-778.
Article
CAS
PubMed
Google Scholar
Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A: Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 2010, 77: 101-109. 10.1038/ki.2009.421.
Article
CAS
PubMed
Google Scholar
Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S: Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 2009, 64: 753-761. 10.1007/s00280-008-0924-2.
Article
CAS
PubMed
Google Scholar
Izuhara Y, Nangaku M, Inagi R, Tominaga N, Aizawa T, Kurokawa K, van Ypersele de Strihou C, Miyata T: Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering. J Am Soc Nephrol. 2005, 16: 3631-3641. 10.1681/ASN.2005050522.
Article
CAS
PubMed
Google Scholar
Mogensen CE: Microalbuminuria as a predictor of clinical diabetic nephropathy. Kidney Int. 1987, 31: 673-689. 10.1038/ki.1987.50.
Article
CAS
PubMed
Google Scholar
Ohtomo S, Izuhara Y, Takizawa S, Yamada N, Kakuta T, van Ypersele de Strihou C, Miyata T: Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model. Kidney Int. 2007, 72: 1512-1519. 10.1038/sj.ki.5002570.
Article
CAS
PubMed
Google Scholar
Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H, Li R: Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett. 2008, 441: 167-172. 10.1016/j.neulet.2008.05.077.
Article
CAS
PubMed
Google Scholar
Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008, 28: 137-143. 10.1016/j.nutres.2008.01.008.
Article
CAS
PubMed
Google Scholar