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  1. Content type: Study protocol

    Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the...

    Authors: Ryosuke Kurokawa, Tomoki Seo, Bunpei Sato, Shin-ichi Hirano and Fumitake Sato

    Citation: Medical Gas Research 2015 5:13

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  2. Content type: Review

    Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. M...

    Authors: Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama and Kinji Ohno

    Citation: Medical Gas Research 2015 5:12

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  3. Content type: Commentary

    Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating...

    Authors: Qin Hu, Anatol Manaenko, Zhenni Guo, Lei Huang, Jiping Tang and John H. Zhang

    Citation: Medical Gas Research 2015 5:10

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  4. Content type: Research

    New gas therapies using inert gases such as xenon and argon are being studied, which would require chronically administered repeating doses. The pharmacokinetics of this type of administration has not been add...

    Authors: Ira Katz, Jacqueline Murdock, Marc Palgen, Jan Pype and Georges Caillibotte

    Citation: Medical Gas Research 2015 5:8

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  5. Content type: Research

    This study investigated the therapeutic effects of hyperbaric oxygen in experimental acute distal colitis focusing on its effect on the production of pro-inflammatory cytokines, nitric oxide and hypoxia-induci...

    Authors: Rogério S Parra, Alexandre H Lopes, Eleonora U Carreira, Marley R Feitosa, Fernando Q Cunha, Sérgio B Garcia, Thiago M Cunha, José J R da Rocha and Omar Féres

    Citation: Medical Gas Research 2015 5:6

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  6. Content type: Research

    Peripheral arterial disease (PAD) affects millions of Americans and leads to critical limb ischemia (CLI) in the most severe cases. Investigators have demonstrated the utility of hydrogen sulfide for restoring...

    Authors: John William Langston and Christopher F Toombs

    Citation: Medical Gas Research 2015 5:5

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  7. Content type: Research

    In experimental periodontitis, non-steroidal antiinflammatory drugs (NSAIDs) effectively inhibit the resultant alveolar bone loss. However, their deleterious gastric effects, observed in both animals and human...

    Authors: Bruno Schneider Herrera, Leila Santana Coimbra, Agatha Ribeiro da Silva, Simone Aparecida Teixeira, Soraia Katia Pereira Costa, John Lawrence Wallace, Luis Carlos Spolidorio and Marcelo Nicolas Muscara

    Citation: Medical Gas Research 2015 5:4

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  8. Content type: Review

    Hyperbaric oxygen therapy (HBOT) is defined as a treatment in which a patient intermittently breathes 100% oxygen while the treatment chamber is pressurized to a pressure greater than sea level (1.0 atmosphere...

    Authors: Ling Yan, Ting Liang and Oumei Cheng

    Citation: Medical Gas Research 2015 5:3

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  9. Content type: Research

    Sperm motility is a critical factor in male fertility. Low motility can be caused by a variety factors including abnormal spermatogenesis, oxidative damage, or depletion of intracellular ATP. Recent findings i...

    Authors: Kumiko Nakata, Naoki Yamashita, Yoshihiro Noda and Ikuroh Ohsawa

    Citation: Medical Gas Research 2015 5:2

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  10. Content type: Research

    Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Hydrogen sulfide (H2S) plays an important role in physiology and pathophysiology of liver. However, whether exogenous H2S...

    Authors: Dongdong Wu, Nairui Zheng, Kunqing Qi, Huijun Cheng, Ziqiang Sun, Biao Gao, Youjing Zhang, Wuyan Pang, Chaoshen Huangfu, Shaoping Ji, Mengzhou Xue, Ailing Ji and Yanzhang Li

    Citation: Medical Gas Research 2015 5:1

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  11. Content type: Research

    Systemic administration of γ-amino-butyric acid type A (GABA-A) and benzodiazepine receptor agonists has been reported to block the development of locomotor sensitization to amphetamine. Here, we investigated ...

    Authors: Hélène N David, Martine Dhilly, Géraldine Poisnel, Mickael Degoulet, Cédric Meckler, Nicolas Vallée, Jean-Éric Blatteau, Jean-Jacques Risso, Marc Lemaire, Danièle Debruyne and Jacques H Abraini

    Citation: Medical Gas Research 2014 4:21

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  12. Content type: Research

    Coronary artery disease remains the principal cause of death in patients with diabetes mellitus. Diabetic mice display exacerbated injury following myocardial ischemia-reperfusion (MI/R) and are resistant to m...

    Authors: Jonathan P Lambert, Chad K Nicholson, Hena Amin, Sana Amin and John W Calvert

    Citation: Medical Gas Research 2014 4:20

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  13. Content type: Review

    Hydrogen, the simplest gas in nature, was recently reported as a therapeutic antioxidant through selectively reducing cytotoxic oxygen radicals. Though hundreds of studies on curative effects of hydrogen were ...

    Authors: Xiao Zhai, Xiao Chen, Shigeo Ohta and Xuejun Sun

    Citation: Medical Gas Research 2014 4:19

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  14. Content type: Review

    Hydrogen is the most abundant chemical element in the Universe, but is seldom regarded as a therapeutic agent. Recent evidence has shown that hydrogen is a potent antioxidative, antiapoptotic and anti-inflamma...

    Authors: Meihua Shen, Hongying Zhang, Congjun Yu, Fan Wang and Xuejun Sun

    Citation: Medical Gas Research 2014 4:17

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  15. Content type: Research

    Recent data suggests that high-flow oxygen started promptly after stroke symptom onset salvages ischemic brain tissue. We investigated the consistency of oxygen delivery to suspected stroke patients in the pre...

    Authors: Yu-Feng Yvonne Chan, Maya Katz, Ari Moskowitz, Steven R Levine, Lynne D Richardson, Stanley Tuhrim, Kevin Chason, Kelly Barsan- Silverman and Aneesh Singhal

    Citation: Medical Gas Research 2014 4:16

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  16. Content type: Research

    Normobaric hyperoxia (NBO) therapy is neuroprotective in acute ischemic stroke. However, how long the NBO should last to obtain optimal outcome is still unclear. Reports show that ischemic penumbra blood suppl...

    Authors: Zhongrui Yuan, Rong Pan, Wenlan Liu and Ke Jian Liu

    Citation: Medical Gas Research 2014 4:14

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  17. Content type: Review

    The increasing demand for organ allografts to treat end-stage organ failure has driven changes in traditional donor criteria. Patients who have succumbed to carbon monoxide (CO) poisoning, a common cause of to...

    Authors: Noritomo Fujisaki, Atsunori Nakao, Takaaki Osako, Takeshi Nishimura, Taihei Yamada, Keisuke Kohama, Hiroyuki Sakata, Michiko Ishikawa-Aoyama and Joji Kotani

    Citation: Medical Gas Research 2014 4:13

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  18. Content type: Research

    Approximately 40% of hemorrhagic stroke survivors develop hydrocephalus. Hyperbaric oxygen (HBO) has been shown to be anti-inflammation following experimental stroke; however, its effect upon post-hemorrhagic ...

    Authors: Qin Hu, Alexander Vakhmjanin, Bo Li, Jiping Tang and John H Zhang

    Citation: Medical Gas Research 2014 4:12

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  19. Content type: Research

    Argon treatment following experimental neurotrauma has been found neuroprotective in an array of in vivo and in vitro models. The inherent cellular and molecular mechanisms are still unknown. We seeked to shed li...

    Authors: Astrid V Fahlenkamp, Mark Coburn, Antonio de Prada, Nadine Gereitzig, Cordian Beyer, Hajo Haase, Rolf Rossaint, Jens Gempt and Yu-Mi Ryang

    Citation: Medical Gas Research 2014 4:11

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  20. Content type: Review

    Neurocognitive deficits remain a significant source of morbidity in survivors of cardiac arrest. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival fol...

    Authors: Lei Huang, Patricia M Applegate, Jason W Gatling, Dustin B Mangus, John Zhang and Richard L Applegate II

    Citation: Medical Gas Research 2014 4:10

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  21. Content type: Review

    Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous ci...

    Authors: Dustin B Mangus, Lei Huang, Patricia M Applegate, Jason W Gatling, John Zhang and Richard L Applegate II

    Citation: Medical Gas Research 2014 4:9

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  22. Content type: Research

    As life expectancy increases, more patients ≥65 years undergo general anesthesia. Anesthetic agents may contribute to postoperative cognitive dysfunction, and incidence may differ with anesthetic agents or int...

    Authors: Minhthy Meineke, Richard L Applegate II, Thomas Rasmussen, Donald Anderson, Sherif Azer, Ali Mehdizadeh, Amy Kim and Martin Allard

    Citation: Medical Gas Research 2014 4:6

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  23. Content type: Research

    Anesthesia with multiple exposures of commonly used inhalation anesthetic sevoflurane induces neuroinflammation and cognitive impairment in young mice, but anesthesia with a single exposure to sevoflurane does...

    Authors: Lei Zhang, Jie Zhang, Yuanlin Dong, Celeste A Swain, Yiying Zhang and Zhongcong Xie

    Citation: Medical Gas Research 2014 4:5

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  24. Content type: Research

    Previously, we reported that menadione activated rat, native heme oxygenase-2 (HO-2) and human recombinant heme oxygenase-2 selectively; it did not activate spleen, microsomal heme oxygenase-1. The purpose of ...

    Authors: Dragic Vukomanovic, Mona N Rahman, Yaroslav Bilokin, Andriy G Golub, James F Brien, Walter A Szarek, Zongchao Jia and Kanji Nakatsu

    Citation: Medical Gas Research 2014 4:4

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  25. Content type: Research

    Nitric oxide (NO) is currently administered using devices that maintain constant inspired NO concentrations. Alternatively, devices that deliver a pulse of NO during the early phase of inspiration may have use...

    Authors: Andrew R Martin, Chris Jackson, Ira M Katz and Georges Caillibotte

    Citation: Medical Gas Research 2014 4:1

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  26. Content type: Research

    Recent studies have revealed the biological effects of H2 in suppressing organ injuries due to acute inflammation and oxidative stress. Dahl salt-sensitive (SS) rats naturally develop elevated blood pressure (BP)...

    Authors: Wan-Jun Zhu, Masaaki Nakayama, Takefumi Mori, Kiyotaka Hao, Hiroyuki Terawaki, Junichiro Katoh, Shigeru Kabayama and Sadayoshi Ito

    Citation: Medical Gas Research 2013 3:26

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  27. Content type: Research

    Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents for arthritic patients, although gastric effects limit their long-term use. Considering the reported gastric safety of hydr...

    Authors: Eduardo Ekundi-Valentim, Filiphe PN Mesquita, Karen T Santos, Marco A Vieira de Paula, Juliana Florenzano, Cristiane I Zanoni, Leandro Rodrigues, Gilberto de Nucci, Simone A Teixeira, Heloisa HA Ferreira, John L Wallace, Soraia KP Costa and Marcelo N Muscará

    Citation: Medical Gas Research 2013 3:24

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  28. Content type: Review

    Hypercapnic acidosis has been regarded as a tolerated side effect of protective lung ventilation strategies. Various in vivo and ex vivo animal studies have shown beneficial effects in acute lung injury settin...

    Authors: Alexander F Bautista and Ozan Akca

    Citation: Medical Gas Research 2013 3:23

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  29. Content type: Review

    Argon is a noble gas in group 18 of the periodic table. Certificated to exist in air atmosphere merely one century ago, discovery of argon shows interesting stories of researching and exploring. It was assumed...

    Authors: Zhouheng Ye, Rongjia Zhang and Xuejun Sun

    Citation: Medical Gas Research 2013 3:22

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  30. Content type: Research

    Pressure ulcer (PU) is common in immobile elderly patients, and there are some research works to investigate a preventive and curative method, but not to find sufficient effectiveness. The aim of this study is...

    Authors: Qiang Li, Shinya Kato, Daigo Matsuoka, Hiroshi Tanaka and Nobuhiko Miwa

    Citation: Medical Gas Research 2013 3:20

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  31. Content type: Review

    The noble gas helium has many applications owing to its distinct physical and chemical characteristics, namely: its low density, low solubility, and high thermal conductivity. Chiefly, the abundance of studies...

    Authors: Carlos J Berganza and John H Zhang

    Citation: Medical Gas Research 2013 3:18

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  32. Content type: Review

    Research of medical gases is well established in Poland and has been marked with the foundation of several professional societies. Numerous academic centers including those dealing with hyperbaric and diving m...

    Authors: Robert P Ostrowski and Emanuela B Pucko

    Citation: Medical Gas Research 2013 3:17

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  33. Content type: Study protocol

    Following radiotherapy, many patients with osteoradionecrosis suffer from xerostomia, thereby decreasing their quality of life. Patients can develop problems with speech, eating, increased dental caries, dysph...

    Authors: Tiffany Hadley, Cassaundra Song, Lauren Wells, Jennifer Lehnhardt, Marcy Wells Rogers, Jeffery Anderson, Michael Terry, Brian Novy and Takkin Lo

    Citation: Medical Gas Research 2013 3:15

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  34. Content type: Research

    Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of...

    Authors: Hiroyuki Terawaki, Yoshimitsu Hayashi, Wan-Jun Zhu, Yukie Matsuyama, Tomoyoshi Terada, Shigeru Kabayama, Tsuyoshi Watanabe, Seiichi Era, Bunpei Sato and Masaaki Nakayama

    Citation: Medical Gas Research 2013 3:14

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  35. Content type: Case report

    Most of the results regarding hydrogen (H2) therapy for acute cerebral ischemia are derived from in vitro studies and animal experiments, with only a few obtained from human trials with a limited number of subjec...

    Authors: Kimihiro Nagatani, Hiroshi Nawashiro, Satoru Takeuchi, Satoshi Tomura, Naoki Otani, Hideo Osada, Kojiro Wada, Hiroshi Katoh, Nobusuke Tsuzuki and Kentaro Mori

    Citation: Medical Gas Research 2013 3:13

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  36. Content type: Research

    High costs still limits the widespread use of xenon in the clinical practice. Therefore, we evaluated xenon consumption of different delivery modes during general surgery.

    Authors: Christian Stoppe, Achim Rimek, Rolf Rossaint, Steffen Rex, Ana Stevanovic, Gereon Schälte, Astrid Fahlenkamp, Michael Czaplik, Christian S Bruells, Christian Daviet and Mark Coburn

    Citation: Medical Gas Research 2013 3:12

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